Efficacy of Non-Invasive Mechanical Ventilation in Early Hypoxia Secondary to Thoracic Trauma

Post-Traumatic Respiratory Failure Clinical Trial

Official title: Non-Invasive Ventilation in Early Severe Posttraumatic Hypoxia: a Randomized Controlled Trial

Status Terminated

Clinical Trial Summary

• Severe post-traumatic hypoxia is mainly due to lung contusion. The intubation rate of these patients is near 20%.

• Treatment before intubation is needed, is based on pain control with epidural anesthesia and oxygen.

• The investigators' hypothesis is that adding non-invasive mechanical ventilation to the standard treatment can reduce the intubation rate if applied early in the course of the disease.

• As thoracic trauma is often associated with injuries in other body regions that may increase the complications of the technique, specific contraindications have been described.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention

Related Conditions & MeSH terms

• Post-Traumatic Respiratory Failure
• Respiratory Insufficiency

• NCT number: NCT00557752
• Study type: Interventional
• Source: Hospital Virgen de la Salud
• Status: Terminated
• Phase: Phase 4
• Start date: September 2005
• Completion date: June 2008