Other Clinical Trial - Efficacy & Safety of Milrinone Versus Sildenafil in

Clinical Trial Description

40 neonates with PPHN, met inclusion criteria, randomly assigned to 2 groups, each includes 20, first group received intravenous milrinone and second group received nasogastric sildenafil. both groups receive other supportive care. ;

Study Design

Related Conditions & MeSH terms

Hypertension
Hypertension, Pulmonary
Persistent Pulmonary Hypertension

See also
Status	Clinical Trial	Phase
Completed	`NCT01310153` - Effect of Supine or Prone Position After Caesarean Birth	N/A
Withdrawn	`NCT00216931` - Treatment of Elevated Arterial Pulmonary Pressure With Inhaled Iloprost	N/A
Terminated	`NCT01409031` - Study of Sildenafil to Treat Newborns With Persistent Pulmonary Hypertension	Phase 2

See also

Status

Clinical Trial

Phase

Completed

NCT01310153 - Effect of Supine or Prone Position After Caesarean Birth

N/A

Withdrawn

NCT00216931 - Treatment of Elevated Arterial Pulmonary Pressure With Inhaled Iloprost

N/A

Terminated

NCT01409031 - Study of Sildenafil to Treat Newborns With Persistent Pulmonary Hypertension

Phase 2

Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.

Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.

Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

NCT number	NCT04391478
Study type	Interventional
Source	Ain Shams University
Contact
Status	Completed
Phase	Phase 1
Start date	January 2015
Completion date	September 2015

Efficacy and Safety of Milrinone Versus Sildenafil in the Treatment of Neonates With Persistent Pulmonary Hypertension — ESMPPHTN

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms