Efficacy of Roflumilast in Prevention of Peripheral Neuropathy

Status Not yet recruiting

Clinical Trial Summary

There are several mechanisms concerning pathophysiology of paclitaxel induced peripheral neuropathy. One of the main mechanisms is induction of Schwann cell dedifferentiation by paclitaxel. At the preclinical level, roflumilast potently inhibited paclitaxel-induced dedifferentiation of cultured Schwann cells, yet this positive effect have not been clinically investigated.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Peripheral Nervous System Diseases
Peripheral Neuropathy

Clinical Trial Details

NCT number	NCT05884281
Study type	Interventional
Source	Mansoura University
Contact
Status	Not yet recruiting
Phase	Phase 1/Phase 2
Start date	July 2023
Completion date	December 2023

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