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Quantification of CD163 Inflammatory Biomarker in Chronic Periodontitis and Diabetic Subjects

Periodontal Diseases Clinical Trial

Official title:
Quantification of CD163 Inflammatory Biomarker in Subgingival Plaque Samples of Generalized Chronic Periodontitis With or Without Type II Diabetes Mellitus

Clinical Trial Summary

The quantification of CD163 will be analysed in the subgingival plaque samples of generalized chronic periodontitis patients with and without diabetes mellitus. The demographic and the periodontal parameters were assessed and the correlated with the quantification of the CD163. The CD163 gene expression was analyzed with RT-PCR and the quantification of CD163 will be done using ELISA.

Clinical Trial Description

The quantification of CD163 will be analysed in the subgingival plaque samples of generalized chronic periodontitis patients with and without diabetes mellitus. A total of 80 subjects with generalized chronic periodontitis were selected and divided into two groups. Group I comprised of 40 subjects who were diagnosed with generalized chronic periodontitis without any systemic conditions. Group II comprised of 40 generalized chronic periodontitis patients with type II diabetes mellitus. Demographic variables such as age, weight, height, BMI and income and the clinical parameters such as plaque index, bleeding on probing, probing pocket depth and clinical attachment level were recorded. Subgingival plaque samples were collected from both the groups.The collected samples were subjected to further molecular analysis for the CD163 expression using RT-PCR and for the CD163 quantification using ELISA. The elevated levels of CD163 in the subgingival plaque samples of generalized chronic periodontitis subjects with diabetes is expected and the early identification of patients at risk for diabetes mellitus and periodontitis. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03727035
Study type Observational
Source Meenakshi Ammal Dental College and Hospital
Contact Jaideep Mahendra, MDS;PhD
Phone 9444963973
Email jaideep_m_23@yahoo.co.in
Status Recruiting
Phase
Start date February 10, 2018
Completion date December 15, 2019
View Details
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