Maternal Periodontal Status and Cytokines in Preeclampsia

Periodontal Diseases Clinical Trial

Official title:

Maternal Periodontal Status and Gingival Crevicular Fluid Levels of Interleukin-6, Interleukin-35, and Interleukin-37 in Preeclampsia

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03088228
• Other study ID #: 2015-HIZ-DF306
• Status: Completed
• Phase: N/A
• First received: February 16, 2017
• Last updated: September 26, 2017
• Start date: February 2, 2015
• Est. completion date: December 31, 2016

Study information

• Verified date: September 2017
• Source: Yuzuncu Yil University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

Background: The purpose of this study is to examine the relationship between maternal preeclampsia and periodontal parameters and the correlation of these two disorders with maternal gingival crevicular fluid levels (GCF) of interleukin (IL)-35, interleukin-37 and interleukin-6. The investigators also investigated their relation to the severity of preeclampsia.

Methods: 82 preeclamptic women were recruited to the study (29 healthy pregnant women, 30 mild preeclamptic patient, 23 severe preeclamptic patient ). The clinical periodontal parameters and GCF samples were collected in the first day of puerperium.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 80
• Est. completion date: December 31, 2016
• Est. primary completion date: August 15, 2016
• Gender: Female
• Age group: 18 Years to 45 Years

Eligibility

Inclusion Criteria:

• Aged between 18 and 45 years

• 25 and 40 weeks of gestation.

• Healthy pregnants, mild and severe preeclampsia

Exclusion Criteria:

• Patients with accompanying diseases

• multiple gestations

• congenital abnormalities were excluded from the study.

Related Conditions & MeSH terms

• Gingival Diseases
• Periodontal Diseases
• Pre-Eclampsia
• Preeclampsia

Intervention

Diagnostic Test:
• gingival crevicular fluid collection

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Hacer Sahin Aydinyurt

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	maternal periodontal clinical parameters and IL-37 and IL-35 and IL-6 levels	IL-37 IL-35 and IL-6 levels in maternal gingival crevicular fluid levels between the three groups	6 months