Periodontal Diseases Clinical Trial
Official title:
Acute Phase Response Following Full Mouth Versus Quadrant Non-Surgical Periodontal Treatment. A Randomized Clinical Trial
This study has compared quadrant scaling and root planing (Q-SRP) versus intensive treatment performed within 24 hours (FM-SRP) in terms of acute phase responses following treatment of periodontal disease. The primary aim was to compare the differences in CRP acute increase following FM-SRP versus Q-SRP therapy (24 hours after therapy). Secondary outcomes included changes in a broad array of inflammatory and endothelial injury markers between groups. Patients were randomly assigned to either FM-SRP and Q-SRP. Data indicated that non-surgical periodontal therapy performed within 24 hours induced greater perturbations of systemic inflammation compared to conventional treatment.
Aim. A moderate acute-phase response occurs 24 hours following full-mouth non-surgical
treatment (FM-SRP). Aim of this study will be to compare quadrant scaling (Q-SRP) versus
FM-SRP in terms of systemic acute (24 hours) and medium-term (3 months) inflammation.
Material & Methods. 38 periodontitis-affected subjects will be randomly allocated to FM-SRP
or Q-SRP after a baseline visit. Periodontal and anthropometric parameters, such as systolic
and diastolic bood pressure, BMI and temperature, will be collected at baseline and 3
months. Serum samples will be drawn at baseline, 1, 7 and 90 days after treatment. High
sensitivity assays for a broad array of inflammatory (PCR, IL-6, TNF-alpha) and endothelial
assays will be performed.
;
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Investigator, Outcomes Assessor), Primary Purpose: Treatment
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