Role of Mechanical Load on Metabolic Exercise Adaptations in Response to Weight Loss in Obese Adolescents: The POWELL Study

Pediatric Obesity Clinical Trial

— POWELL  

Official title:

Role of Mechanical Load on Metabolic Exercise Adaptations in Response to Weight Loss in Obese Adolescents: The POWELL Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04902001
• Other study ID #: RBHP 2021 BOIRIE
• Secondary ID: 2021-A00756-35
• Status: Completed
• Phase: N/A
• Start date: August 20, 2021
• Est. completion date: April 25, 2022

Study information

• Verified date: June 2022
• Source: University Hospital, Clermont-Ferrand
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

While interdisciplinary weight loss intervention have been shown successful among adolescents with obesity, a weight regain is most of the time observed within the following weeks or months. The aim of the present project will be to better identify the independent role played by both the metabolic and mechanical load and their modification during weight loss, on the energy expenditure and energy metabolism of adolescents with obesity.

Description:

A total of 28 adolescents with obesity will be recruited from our local inpatient pediatric obesity centers. Before their weight loss intervention the adolescents will complete two experimental visits. During the first visit, anthropometric and body composition measurements will be performed. Then the participants will be asked to complete a walking exercise on a treadmill during the second visit. Their energy expenditure and substrate oxidation will be assessed by indirect calorimetry. They will have to walk at 5 different walking speeds. Then, they will follow a 12-week weight loss intervention. By the end of this intervention, their body composition will be assessed and they will be asked to perform the same walking exercise. On a separate occasion (randomly assigned) they will have to repeat this walking exercise while carrying a load corresponding of their weight loss.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 21
• Est. completion date: April 25, 2022
• Est. primary completion date: April 25, 2022
• Accepts healthy volunteers: No
• Gender: All
• Age group: 12 Years to 16 Years

Eligibility

Inclusion Criteria:

• being aged 12-16 years old

• no contraindication to physical exercise

• no cardiovascular disease

• BMI above the 97th percentile

• candidate to a weight loss intervention

Exclusion Criteria:

• surgery and medical conditions preventing them to perform the intervention

• Weight loss during the previous 6 months

• medication that could interfere with energy metabolism.

• pregnancy

• regular tobacco and alcool use

Related Conditions & MeSH terms

• Pediatric Obesity
• Weight Loss

Intervention

Behavioral:
• Multidisciplinary weight loss
The adolescents will follow a 12-week intervention combining nutritional education, physical activity 3 times per week and psychological supports.

Locations

Country	Name	City	State
France	CHU clermont-ferrand	Clermont-Ferrand

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Clermont-Ferrand

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in Energy Expenditure between before and after weight loss	amount of energy expended during the walking tests, measured using indirect calorimetry	before and after the 12-week weight loss
Secondary	change in lipid oxidation between before and after weight loss	amount of lipids oxidized during the walking tests, measured using indirect calorimetry	before and after the 12-week weight loss
Secondary	change in Fat mass between before and after weight loss	The amount of body fat will be assessed by dual energy X-ray absorptiometry	before and after the 12-week weight loss
Secondary	change physical activity preferences between before and after weight loss	Children will be asked to indicate their prefered physical activties and sedenatry behaviors on a computer task using visual analog scale (from 0 to 150 mm)	before and after the 12-week weight loss intervention
Secondary	Change in Energy Expenditure between the unloaded and loaded walking test	amount of energy expended during the walking tests, measured using indirect calorimetry	after the 12_week weight loss
Secondary	Change in lipid oxidation between the unloaded and loaded walking test	amount of lipids oxidized during the walking tests, measured using indirect calorimetry	after the 12_week weight loss