Parkinson's Disease Clinical Trial
Official title:
Proteomics, Metabolomics, Lipidomics and Genetic Analysis for Biomarker DISCOVERY in Parkinson's Disease
There are approximately one million Americans who live with Parkinson's disease with 50,000
new cases per year and this rate is expected to rise with an aging population. The
underlying pathophysiology and disease understanding of PD still remains elusive due to a
combination of disease complexity and lack of predictive capability of existing models.
The Berg Interrogative Biology™ discovery platform has demonstrated a unique capability in
producing drug targets and biomarkers that truly represent a disease phenotype. It has been
able to catalyze molecules now in late stage clinical trials in cancer and many pre-clinical
candidate therapeutics and biomarkers in endocrinology and central nervous system (CNS)
diseases. The platform is able to decipher normal versus disease signatures by integration
of data sets from the genome, metabolome, proteome, and lipidome in an agnostic manner that
is subjected to Bayesian Artificial Intelligence informatics. The resulting nodes are then
put back into wet-lab validation before proceeding to proof-of-principle pre-clinical
testing.
By utilizing clinical data and specimens obtained by the medical specialists at The
Parkinson's Institute, along with Berg's Interrogative Biology™, this study aims to discover
a disease biomarker enabling the creation of a diagnostic test for Parkinson's disease.
n/a
Observational Model: Case Control, Time Perspective: Cross-Sectional
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