Parkinson's Disease Clinical Trial
Official title:
Cognitive Impairment in Parkinson's Disease Categorised in Accordance to Motor Symptoms -the Relation Between Cognitive Deficits and Comorbid Psychiatric Disorders, Medication, and Age at Disease Onset
Background: Approximately 40% of patients with Parkinson's disease (PD) have cognitive
impairments. There is a lack of consensus as to the extent to which psychiatric symptoms,
depression, age at disease onset, disease duration, and medication is related to the type
and severity of cognitive impairment. This discrepancy can in part be caused by the lack of
distinction between patients with different motor symptoms and disease severity.
Objective: To identify the extent to which psychiatric symptoms, depression, age at disease
onset, disease duration, and medication is related to the severity and type of cognitive
dysfunction in patients with idiopathic PD categorized according to motor symptoms and
disease severity.
Methods: the population of patients with PD in the old county of Aarhus is described on the
background of medical records, and stratified in accordance to age, sex and cardinal
symptoms. Through proportional allocation a sample of a minimum of 50 patients with PD is
drawn from the population. The patients and 30 healthy matched controls will undergo
comprehensive neuropsychological assessment including tests of language, memory, executive
function, and visuospatial function. Furthermore, all participants will be screened for
depression (Geriatric Depression Scale) and psychiatric symptoms (Neuropsychiatric Inventory
and Symptom Checklist). The patients will be categorized in accordance with their motor
symptoms via cluster analysis for the purpose of analyzing the effect of psychiatric
symptoms, depression, and age of disease onset, disease duration, and medication on
cognition.
n/a
Observational Model: Cohort, Time Perspective: Cross-Sectional
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