Parkinson's Disease Clinical Trial
Official title:
Parkinson's Disease Evaluated by Positron Emission Tomography and the Effect of the NMDA Receptor Antagonist Memantine
Purpose of study: To investigate whether the NMDA antagonist Memantine has a substantial
effect of brain metabolism in patients with Parkinson's disease (PD), using Positron
Emission Tomography (PET).
Background: Disturbances in brain metabolism is thought to contribute to degeneration of
neurons in brain of PD patients. Production of toxic oxygen radicals and presence of too
much excitatory neurotransmitter (glutamate) due to over activity is involved. These factors
can theoretically be alleviated by memantine.
Hypothesis: Memantine decreases metabolism in areas in PD brain known to be over-active.
Decreases in cerebral blood flow and oxygen metabolism in these areas will be the
consequence and this can be detected by PET.
n/a
Allocation: Non-Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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