Ovarian Cancer Clinical Trial
Official title:
DNA Methylation as a Predictor for Response and Progression-Free Survival in Patients With Ovarian Cancer
RATIONALE: Studying tissue and blood samples from patients with cancer in the laboratory may
help doctors learn more about changes that occur in DNA and identify biomarkers related to
cancer. It may also help doctors predict how patients respond to treatment.
PURPOSE: This laboratory study is evaluating DNA to see how well it predicts response to
treatment in patients with stage I, stage II, stage III, or stage IV ovarian epithelial
cancer.
OBJECTIVES:
- To determine if DNA methylation patterns and expression of differentially methylated
genes taken before chemotherapy can predict patient outcome with regard to
progression-free survival.
- To evaluate whether DNA methylation can predict response assessed by RECIST criteria
and CA 125 response.
- To evaluate the specificity and sensitivity of predicting methylation changes in tumor
from the changes at the corresponding CpG islands in plasma.
OUTLINE: Tumor samples are collected at the time of initial laparotomy and blood is drawn
prior to surgery for DNA methylation and biomarker studies.
Changes in DNA methylation will be examined globally using DNA methylation hybridization to
microarrays and methylation specific PCR, as well as expression of genes shown to be
differentially methylated.
;
Observational Model: Case-Only, Time Perspective: Prospective
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