Ovarian Cancer Clinical Trial
Official title:
Phase II Study on ET-743 in Advanced Soft Tissue Sarcomas of the Adult
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing
so they stop growing or die.
PURPOSE: Phase II trial to study the effectiveness of ecteinascidin 743 in treating patients
who have advanced soft tissue sarcoma.
OBJECTIVES: I. Determine the therapeutic activity of ecteinascidin 743 in patients with
advanced soft tissue sarcomas. II. Determine the duration of response in these patients.
III. Determine the acute side effects in these patients.
OUTLINE: This is a multicenter study. Patients receive ecteinascidin 743 (ET-743) IV over 24
hours every 3 weeks. Treatment continues for at least 2-6 courses in the absence of disease
progression or unacceptable toxicity. Patients are followed every 6 weeks until disease
progression and every 12 weeks after disease progression.
PROJECTED ACCRUAL: Approximately 28-44 patients will be accrued for this study.
;
Primary Purpose: Treatment
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