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Clinical Trial Summary

This is a prospective, multicenter, randomized phase III trial among women with endometrioid adenocarcinoma with high-intermediate and intermediate risk features to investigate the role of integrated genomic-pathologic classification to determine if participants should receive no adjuvant therapy, vaginal brachytherapy, external beam radiotherapy or chemo-radiation therapy based on molecular features as compared to standard radiation therapy.


Clinical Trial Description

Adjuvant therapy for women with endometrial cancer has increasingly been tailored to prognostic factors to prevent overtreatment and select those women for adjuvant treatment who will have a clinically relevant reduction of the risk of relapse by the adjuvant treatment. Risk profiles have traditionally been based on clinicopathological factors such as age, stage, grade, LVSI and depth of invasion. Newer, both molecular-genetic (the cancer genome atlas subgroups) have become available which are strongly related to outcomes and risk of cancer spread. Based on the recent 2022 NCCN guideline and Portec-4a study, this randomized trial using integrated genomic-pathologic classification to assign adjuvant treatment for women with stage I-II high-intermediate and intermediate risk endometrioid adencarcinoma. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05179447
Study type Interventional
Source Women's Hospital School Of Medicine Zhejiang University
Contact Xinyu Wang, MD
Phone +86-571-87061501
Email [email protected]
Status Not yet recruiting
Phase N/A
Start date January 1, 2022
Completion date January 1, 2026

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