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Clinical Trial Summary

Spontaneous bacterial peritonitis (SBP) is an infection of the peritoneal cavity with no surgically treatable intra-abdominal source of infection. Spontaneous peritonitis is a potentially fatal complication in patients with advanced liver cirrhosis. It is estimated that 10-20 % of patients with cirrhotic ascites may develop spontaneous peritonitis, which is usually caused by a bacterial infection. In contrast, spontaneous fungal peritonitis (SFP) is less well-recognized. SFP may be associated with higher mortality rates than SBP but therapeutic approaches are largely undefined. To this end, the epidemiology and outcomes of patients with SFP have only been documented sporadically aimed to evaluate the risk factors for the development of spontaneous fungal peritonitis (SFP), and the prognosis of SFP compared with SBP


Clinical Trial Description

Cross-sectional study Studied population & locality: Patients with signs and symptoms suggestive of spontaneous peritonitis who will be admitted to Tropical medicine and Gastroenterology or Internal medicine departments in Sohag university hospitals during the period from september 2021 to december 2022 will be included in the study. According to the results of ascitic fluid analysis, we will divide the patients into 2 groups: Group (1): patients with spontaneous bacterial peritonitis (SBP). Group (2): patients with spontaneous fungal peritonitis (SFP). Exclusion criteria: Patients seropositive for human immunodeficiency virus (HIV) and patients undergoing continuous ambulatory peritoneal dialysis were excluded from this study. Methods: All included patients will be subjected to: 1. Detailed history, complete general and systemic examination. 2. Ascitic fluid analysis 3. Bacterial and fungal culture from ascitic fluid: Ten milliliters of ascitic fluid will be collected at the bedside and inoculated into aerobic and anaerobic blood culture bottles. Bacterial culture will be performed manually using MacConkey and blood agar plate. Fungal culture will be performed in the same manner using Emmons Sabouraud dextrose agar (ESDA). Identification of fungus and antifungal susceptibility tests will be performed with an automated VITEK2 system. The ascitic fluid PMN count will be determined simultaneously, and empirical antibiotics will be administered immediately after diagnostic paracentesis. 4. Laboratory investigations: Fasting blood sugar Liver function tests. CBC. Ethical considerations: The study will be approved by The Ethical committee of medical research, Sohag Faculty of Medicine, Sohag University. After an explanation about the nature of the procedures, possible complications, benefits, and steps of the study, all patients and controls will give written informed consent for participating in the study. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05117073
Study type Observational
Source Sohag University
Contact Mona Abdelrahmam, MD
Phone 01021025895
Email [email protected]
Status Recruiting
Phase
Start date September 1, 2021
Completion date August 31, 2023