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Clinical Trial Summary

The best way to titrate positive end-expiratory pressure (PEEP) in patients suffering from acute respiratory distress syndrome is still matter of debate. Electrical impedance tomography (EIT) in a non-invasive technique that could guide PEEP setting based on an optimized ventilation homogeneity.

Clinical Trial Description

COVID-19 related ARDS patients admitted to the ICU in March 2021 requiring mechanical ventilation were enrolled. Patients were monitored by an esophageal catheter and a 32-electrode EIT device. Within 48 hours after the start of mechanical ventilation, different levels of PEEP were applied based upon PEEP/ Fraction of inspired oxygen tables, positive end-expiratory transpulmonary (PL)/ FiO2 table, and EIT. Respiratory mechanics variables were recorded. ;

Study Design

Related Conditions & MeSH terms

  • COVID-19
  • Severe Acute Respiratory Syndrome

NCT number NCT05115526
Study type Observational
Source Central Hospital, Nancy, France
Status Completed
Start date March 1, 2021
Completion date May 1, 2021