Clinical Trials Logo

Clinical Trial Summary

This trial aims to compare the incidence of postoperative residual curarisation (PORC) and postoperative pulmonary complications (PPCs) in the SUG and NEO group by means of diaphragm ultrasonography and LUS, so as to conclude whether SUG can outperform NEO in preventing occurrence of PORC and PPCs.

Clinical Trial Description

The incidence of postoperative residual curarisation (PORC) is about 2%-64% worldwide, which may be an underling risk factor of postoperative pulmonary complications (PPCs), causing many undesirable effects on patients. Thus, reversal drugs of neuromuscular blocking agents (NMBAs) such as neostigmine (NEO) and sugammadex (SUG) have been administrated, and SUG maybe perform better in preventing PORC. Different supplementary methods to help identify PORC or PPCs have also been reported, such as adductor of pollicis acceleromyography and lung ultrasound (LUS). Recently, diaphragm ultrasonography has been used to evaluate PORC, as a novel approach.In this prospective, double-blind, randomized controlled trial, we will enroll 414 patients of American Society of Anesthesiologists physical status I-III, aged over 60 years, who will be scheduled to undergo arthroplasty surgery under general anesthesia. Participants will be randomized into NEO and SUG group receiving neostigmine and sugammadex as reversal drug respectively. The primary outcomes will be the incidence of PPCs in NEO and SUG group respectively. The secondary outcome is the incidence of PORC in the two groups.We hypothesize that: 1) the incidence of PPCs is lower after reversal with SUG than with NEO, 2) using the method of diaphragm ultrasonography, the incidence PORC is lower after reversal with SUG than with NEO, 3) the incidence of PPCs can be predicted by LUS and by evaluating whether there is PORC through diaphragmatic ultrasound. ;

Study Design

Related Conditions & MeSH terms

  • Delayed Emergence from Anesthesia
  • Postoperative Pulmonary Complications

NCT number NCT05040490
Study type Interventional
Source Peking Union Medical College Hospital
Phone +8619801103037
Email [email protected]
Status Not yet recruiting
Phase N/A
Start date August 31, 2021
Completion date September 2022

See also
  Status Clinical Trial Phase
Completed NCT03688724 - Perioperative Diaphragm Point of Care Ultrasound
Completed NCT04605250 - Respiratory Variability for Respiratory Monitoring During the Postoperative Recovery Period N/A
Not yet recruiting NCT02732574 - Oscillating Positive Expiratory Pressure (OPEP) Therapy in High Risk Patients Following Cardiac Surgery N/A
Completed NCT02918877 - Anesthetics to Prevent Lung Injury in Cardiac Surgery Phase 1/Phase 2
Recruiting NCT04408495 - Intraoperative Mechanical Ventilation and Postoperative Pulmonary Complications After On-pump Cardiac Surgery in High-risk Patients N/A
Recruiting NCT04108130 - An Anesthesia-Centered Bundle to Reduce Postoperative Pulmonary Complications: The PRIME-AIR Study N/A
Not yet recruiting NCT01701908 - Postoperative Pulmonary Complications in Abdominal Surgery N/A
Completed NCT03160144 - The PROtective Ventilation Using Open Lung Approach Or Not Trial N/A
Completed NCT02929446 - Mobilization Immediate After Abdominal Surgery N/A
Not yet recruiting NCT03756727 - Effect of Ascorbic Acid on Postoperative Pulmonary Complications in Patients Undergoing Cardiac Surgery Early Phase 1
Recruiting NCT04967651 - Analysis of Risk Factors and Establishment of Early Warning Model for Pulmonary Complications
Completed NCT01321983 - Effects of Preoperative Inspiratory Muscle Training (IMT) in Obese Women Undergoing Open Bariatric Surgery N/A