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Clinical Trial Summary

The objective is to determine if neuraminidase inhibition with zanamivir is efficacious as a therapeutic strategy to restore endothelial function in T2D patients.


Clinical Trial Description

Twenty subjects will complete five days of treatment with zanamivir. Baseline measurements will be taken before the initiation of treatment, as well as after the conclusion of the treatment period (i.e., a total of two assessment visits per subject). Assessment visits will include: vitals (such as blood pressure, heart rate), fasting blood work for plasma neuraminidase activity, plasma sialic acid, plasma glucose and plasma insulin, brachial artery FMD, and glycocalyx integrity assessment via Glycocheck. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04867707
Study type Interventional
Source University of Missouri-Columbia
Contact Luis Martinez-Lemus, PhD
Phone (573) 882-3244
Email [email protected]
Status Not yet recruiting
Phase Phase 2
Start date May 1, 2021
Completion date May 1, 2025

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