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Clinical Trial Summary

The purpose of this study is to use state of the art brain imaging technology to investigate neuroinflammation in participants with depression after the respiratory symptoms of COVID-19 have passed.

Clinical Trial Description

Participants will undergo two PET scans: one [11C]SL25.1188 scan (for TSPO) and one [11C]SL25.1188 scan (for MAO-B) - as well as one MRI scan. The primary hypotheses are: 1. TSPO VT and MAO-B VT are greater in the PFC, ACC, and hippocampus in COVID-19 with new onset, persistent MDE with or without other neuropsychiatric symptoms after recovery from mild respiratory symptoms (DNP-mild). 2. TSPO VT and MAO-B VT are greater in the PFC, ACC, and hippocampus in COVID-19 with new onset, persistent MDE with or without other persistent neuropsychiatric symptoms after recovery from moderate respiratory symptoms (DNP-moderate). Exploratory hypotheses are: 1. Greater TSPO VT and MAO-B VT in the PFC, ACC, and hippocampus will be positively associated with severity of MDE symptoms and poorer performance on cognitive tasks. 2. TSPO VT and MAO-B VT will be positively correlated in the PFC, ACC and hippocampus in COVID-DNP. ;

Study Design

Related Conditions & MeSH terms

NCT number NCT04854785
Study type Observational
Source Centre for Addiction and Mental Health
Contact Joeffre Braga
Phone 416-535-8501
Email [email protected]
Status Recruiting
Start date May 2021
Completion date April 2023

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