Outcome
| Type |
Measure |
Description |
Time frame |
Safety issue |
| Primary |
Blood biomarker associated with a cytokine storm - Pro-Beta Natriuretic Peptide (measured in pg/mL). |
Pro-Beta Natriuretic Peptide (BNP) measured as part of routine clinical care. NHS care teams will upload anonymised routine clinical measurements into a secure study database. |
From date of admission to date of discharge from hospital assessed up to 18 months |
|
| Primary |
Blood biomarker associated with a cytokine storm - Ferritin (measured in µg/L) |
Ferritin measured as part of routine clinical care. NHS care teams will upload anonymised routine clinical measurements into a secure study database. |
From date of admission to date of discharge from hospital assessed up to 18 months |
|
| Primary |
Blood Biomarker associated with a cytokine storm - C-Reactive Protein (measured in mg/L) |
C-Reactive Protein measured as part of routine clinical care. NHS care teams will upload anonymised routine clinical measurements into a secure study database. |
From date of admission to date of discharge from hospital assessed up to 18 months |
|
| Secondary |
Demographic characteristics including age, sex, ethnicity and pre-existing morbidities |
Information collected as part of routine clinical care. NHS clinical care teams will upload anonymous data into a secure study database. |
At admission to hospital |
|
| Secondary |
Hospital stay data |
Information collected as part of routine clinical care. NHS clinical care teams will upload anonymous data into a secure study database. |
From date of admission to date of discharge from hospital assessed up to 18 months |
|
| Secondary |
Cytokine storm biomarker measured in mg/L (CRP) |
Clinical investigations (blood biomarkers) collected as part of routine clinical care |
From date of admission to date of discharge from hospital assessed up to 18 months |
|
| Secondary |
Cytokine storm biomarkers measured in pg/mL (pro-beta natriuretic peptide, IL-6, IFN-gamma, IL-10, TNF-alpha) |
Clinical investigations (blood biomarkers) collected as part of routine clinical care |
From date of admission to date of discharge from hospital assessed up to 18 months |
|
| Secondary |
Full blood count measures in 10^9/L (white cell count - neutrophil and lymphocyte count and platelet) |
Clinical investigations (blood biomarkers) collected as part of routine clinical care |
From date of admission to date of discharge from hospital assessed up to 18 months |
|
| Secondary |
Full blood count measures in L/L (haematocrit) |
Clinical investigations (blood biomarkers) collected as part of routine clinical care |
From date of admission to date of discharge from hospital assessed up to 18 months |
|
| Secondary |
Haemoglobin in g/L or g/dL (measured as part of full blood count and blood gas analysis) |
Clinical investigations (blood biomarkers) collected as part of routine clinical care |
From date of admission to date of discharge from hospital assessed up to 18 months |
|
| Secondary |
Blood gas analysis measured in KPa (pCO2, pO2) |
Clinical investigations (blood biomarkers) collected as part of routine clinical care |
From date of admission to date of discharge from hospital assessed up to 18 months |
|
| Secondary |
Blood gas analysis measured in mmol/l (glucose, lactate, Na, K and Cl) |
Clinical investigations (blood biomarkers) collected as part of routine clinical care |
From date of admission to date of discharge from hospital assessed up to 18 months |
|
| Secondary |
Blood gas analysis measured in mmol/l or mEq/L (HCO3, BE) |
Clinical investigations (blood biomarkers) collected as part of routine clinical care |
From date of admission to date of discharge from hospital assessed up to 18 months |
|
| Secondary |
Liver function tests measured in g/L (protein, albumin, globulin) |
Clinical investigations (blood biomarkers) collected as part of routine clinical care |
From date of admission to date of discharge from hospital assessed up to 18 months |
|
| Secondary |
Liver function tests measured in U/L (ALP/ALT) |
Clinical investigations (blood biomarkers) collected as part of routine clinical care |
From date of admission to date of discharge from hospital assessed up to 18 months |
|
| Secondary |
Liver function tests measured in µmol/L (bilirubin) |
Clinical investigations (blood biomarkers) collected as part of routine clinical care |
From date of admission to date of discharge from hospital assessed up to 18 months |
|
| Secondary |
Troponin measured in ng/ml or ng/L |
Clinical investigations (blood biomarkers) collected as part of routine clinical care |
From date of admission to date of discharge from hospital assessed up to 18 months |
|
| Secondary |
vitamin D measured in nmol/L |
Clinical investigations (blood biomarkers) collected as part of routine clinical care |
From date of admission to date of discharge from hospital assessed up to 18 months |
|
| Secondary |
Amylase, CK, LDH measured in U/L |
Clinical investigations (blood biomarkers) collected as part of routine clinical care |
From date of admission to date of discharge from hospital assessed up to 18 months |
|
| Secondary |
Glucose and triglycerides measured in mmol/L |
Clinical investigations (blood biomarkers) collected as part of routine clinical care |
From date of admission to date of discharge from hospital assessed up to 18 months |
|
| Secondary |
Urea and electrolytes measured in mmol/L (Na, K, urea) |
Clinical investigations (blood biomarkers) collected as part of routine clinical care |
From date of admission to date of discharge from hospital assessed up to 18 months |
|
| Secondary |
Urea and electrolytes measured in µmol/L (creatinine) |
Clinical investigations (blood biomarkers) collected as part of routine clinical care |
From date of admission to date of discharge from hospital assessed up to 18 months |
|
| Secondary |
ferritin measured in µg/L |
Clinical investigations (blood biomarkers) collected as part of routine clinical care |
From date of admission to date of discharge from hospital assessed up to 18 months |
|
| Secondary |
fibrinogen measured in g/L |
Clinical investigations (blood biomarkers) collected as part of routine clinical care |
From date of admission to date of discharge from hospital assessed up to 18 months |
|
| Secondary |
D-dimer measured in ng/ml |
Clinical investigations (blood biomarkers) collected as part of routine clinical care |
From date of admission to date of discharge from hospital assessed up to 18 months |
|
| Secondary |
PT and APTT measured in seconds |
Clinical investigations (blood biomarkers) collected as part of routine clinical care |
From date of admission to date of discharge from hospital assessed up to 18 months |
|
| Secondary |
INR as a ratio (Patient PT/Control PT) |
Clinical investigations (blood biomarkers) collected as part of routine clinical care |
From date of admission to date of discharge from hospital assessed up to 18 months |
|
| Secondary |
Acute Kidney Injury graded as no AKI or stage of AKI (1-3) |
Clinical investigations (blood biomarkers) collected as part of routine clinical care |
From date of admission to date of discharge from hospital assessed up to 18 months |
|
| Secondary |
Positive or negative COVID-19 antibody test |
Clinical investigations (blood biomarkers) collected as part of routine clinical care |
From date of admission to date of discharge from hospital assessed up to 18 months |
|
| Secondary |
Presence or absence of clinical conditions as assessed by ECG/echocardiography |
Conditions will include: myocarditis, valvulitis, pericardial effusion, coronary artery dilation, or other conditions. |
From date of admission to date of discharge from hospital assessed up to 18 months |
|
| Secondary |
Presence or absence of clinical conditions as assessed by chest x-ray/chest CT |
Conditions will include: presence of patchy symmetrical infiltrates, pleural effusion, coronary artery abnormalities (CT with contrast) or other conditions. |
From date of admission to date of discharge from hospital assessed up to 18 months |
|
| Secondary |
Presence or absence of clinical conditions as assessed by abdominal ultrasound |
Conditions will include: colitis, ileitis, lymphadenopathy, ascites, hepatosplenomegaly or other conditions. |
From date of admission to date of discharge from hospital assessed up to 18 months |
|
| Secondary |
Proteinuria as assessed by urinalysis graded as no protein, protein ++ or protein +++ |
|
From date of admission to date of discharge from hospital assessed up to 18 months |
|
| Secondary |
Positive or negative COVID swab result as assessed by PCR |
|
From date of admission to date of discharge from hospital assessed up to 18 months |
|
| Secondary |
Positive or negative NPA or throat swab result for respiratory panel as assessed by PCR |
Including: pneumococcal, meningococcal, Group A Strep, Staph Aureus, EBV, CMV, Andenovirus, Enterovirus |
From date of admission to date of discharge from hospital assessed up to 18 months |
|
| Secondary |
Vaccination status |
Information collected as part of routine clinical care. NHS clinical care teams will upload anonymous data into a secure study database. |
At admission to hospital |
|
