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NCT04144465 Clinical Trial

Noradrenaline Infusion Versus Phenylephrine Infusion in Improving Serum Lactate Level in HIPEC

Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Clinical Trial

Official title:
Effect of Noradrenaline Infusuion Versus Phenyephrine Infusion in Improving Tissue Perfusion in HIPEC

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT04144465
Other study ID # noradrenaline vs phenylephrine
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date November 1, 2019
Est. completion date December 30, 2023

Study information
Verified date May 2024
Source Suez Canal University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

ABG PARAMETERS ARE CHANGED DURING HIPEC, WE TRIED TO FIND COMPARISON BETWEEN NORADRENALINE AND PHENYLEPHRINE IN OPTIMIZING ABG PARAMETERS THAT REFLECTS ORGAN PERFUSIONS ESPECIALLY SERUM LACTATE

Description:

Arterial blood gas testing is considered one of the most important and widely used test in the detection of acidosis, alkalosis, electrolytes disturbance and tissue perfusion. in regard to tissue perfusion serum lactate above 4 mmol/L indicates poor tissue perfusion. serum lactate could be measured at ABG or separately. in this study we will test the effect of both noradrenaline and phenylephrine on lactate level at ABG during the stage of HIPAC in managing abdominal cancer patients.

Recruitment information / eligibility
Status Completed
Enrollment 30
Est. completion date December 30, 2023
Est. primary completion date October 30, 2023
Accepts healthy volunteers No
Gender All
Age group 35 Years and older
Eligibility Inclusion Criteria: - CANCER PATIENTS ENROLLED FOR HIPEC Exclusion Criteria: - DRUG SENSITIVITY

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• NORADRENALIN
DRUG THAT IS IMPROVING TISSUE AND ORGAN PERFUSION
• PHENYLEPHRINE
DRUG THAT IS IMPROVING TISSUE AND ORGAN PERFUSION

Locations
Country Name City State
Egypt Suez Canal University Ismailia

Sponsors (1)
Lead Sponsor Collaborator
Suez Canal University

Country where clinical trial is conducted

Egypt, 

Outcome
Type Measure Description Time frame Safety issue
Primary SERUM LACTATE IN ABG LANDMARK FOR TISSUE AND ORGAN PERFUSION IMMEDIATELY POSTOPERATIVELY