Temporomandibular Joint Disorders Clinical Trial
Official title:
Clinical Study for the Evaluation of the Safety and Effectiveness of Autologous Chondrocytes Transplantation for the Treatment of Condylar Resorption Associated With Dentofacial Deformities
This clinical study has as main objective to evaluate if the Nasal Septum Autologous Chondrocytes Transplantation for Condylar Resorption is safe and effective in the treatment of degenerative lesions of temporomandibular joint (TMJ). It is a case series, in which 10 participants with diagnosis of condylar reabsorption of TMJ will be selected, with orthognathic surgery indicated. Orthognathic surgery is conventionally indicated for patients with condylar resorption to correct dentofacial deformity and, therefore, will not be performed only in function of this clinical study. The selected participants will be submitted to nasal cartilage biopsy, for isolation and preparation of the chondrocytes. The only experimental group to be evaluated will be the group treated with autologous chondrocytes diluted in hyaluronic acid. The experimental treatment will be performed 15 days after orthognathic surgery, and will be injected through arthrocentesis. Clinical follow- up will be performed in the following periods: 7 and 15 days and 1, 3, 6 and 12 months after treatment. During the consultations, participants will also be evaluated for the intensity and severity of the pain experienced, as well as the disability related to it, through the same system used for the diagnostic classification (RDC / TMD). Imaging of the TMJ will be performed before, 6 and 12 months after the injection of the experimental treatment for bone and cartilaginous joint tissue analysis. Autologous chondrocyte implantation is expected to promote the regeneration of TMJ cartilage tissue safely and effectively.
The only experimental group to be evaluated will be the group treated with autologous chondrocytes diluted in hyaluronic acid, to be included in groups of 2, 4 and 4 participants. Only two participants will initially be included. If these two treated participants do not present adverse effects in 3 months, we will start a second stage with 4 participants. Again we will analyze the group over 3 months and if there are no problems we will include the 4 final participants, totaling the 10 participants. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT03675659 -
Intra-articular Magnesium Sulfate for Tmj Dysfunction
|
Early Phase 1 | |
Completed |
NCT05740826 -
Correlation Between Cervical Spine Muscle Disorders and the Occurrence of Symptoms of Temporomandibular Joint Dysfunction
|
||
Recruiting |
NCT05006963 -
Tele-Rehabilitation in Patients With Temporomandibular Dysfunction
|
N/A | |
Active, not recruiting |
NCT06103851 -
Effect of Mask Use on Jaw Functionality
|
||
Not yet recruiting |
NCT02908568 -
Stimulation of the Proprioceptive Trigeminocardiac Reflex
|
Phase 2/Phase 3 | |
Completed |
NCT03119324 -
Low Level Laser Therapy in the Treatment of Temporomandibular Joint Disorders (TMJDs) Related Pain
|
N/A | |
Completed |
NCT02247063 -
Motor Cortex as a Research & Therapeutic Target in TMD
|
N/A | |
Recruiting |
NCT06046521 -
Impact of Temporomandibular Joint Dysfunction on Objective and Subjective Vocal Measures
|
||
Completed |
NCT00009594 -
Alternative Medicine Approaches for Women With Temporomandibular Disorders
|
Phase 2 | |
Completed |
NCT00010621 -
Complementary Medicine Approaches to TMD Pain Management
|
Phase 2 | |
Completed |
NCT06055855 -
Comparing Two-Needle vs. Surgery-Guided Arthrocentesis for TMJ Disorders
|
N/A | |
Recruiting |
NCT06035341 -
The Association Between Temporomandibular Disorders and Sacroiliac Joint Dysfunction
|
N/A | |
Completed |
NCT06005922 -
The Effectiveness of Temporomandibular Joint Mobilization and Exercise in Individuals With Chronic Neck Pain
|
N/A | |
Completed |
NCT06034756 -
Temporomandibular Joint Problems and Core Stabilization
|
||
Completed |
NCT03576079 -
Effect of Laser Therapy Versus Anterior Re-positioning Splint in the Treatment of Disc Displacement With Reduction
|
N/A | |
Completed |
NCT04557878 -
Role of Liquid Phase Concentrated Growth Factors vs. Hypertonic Dextrose Prolotherapy for Management of Patients With Disc Displacement Without Reduction
|
Phase 2 | |
Completed |
NCT04477122 -
Effects of Radial Shock Wave Therapy in the Treatment of Temporomandibular Joint Syndrome.
|
N/A | |
Completed |
NCT00237042 -
Managing Temporomandibular Disorder (TMD) Symptoms
|
N/A | |
Completed |
NCT06132802 -
Evaluation of Anterior Repositioning Guided Splint Combined With or Without I Platelet-rich Fibrin
|
N/A | |
Completed |
NCT06132594 -
Computed Guided Prolotherapy Versus Conventional Prolotherapy
|
N/A |