Clinical Trials Logo

Clinical Trial Summary

The purpose of this study is to test the efficacy and safety of an experimental drug, demcizumab, when given in combination with pembrolizumab. Demcizumab is a humanized monoclonal antibody and was developed to target cancer stem cells. Demcizumab may block the growth of cancer stem cells, the remaining cancer cells, and it may also impair the productive growth of new blood vessels, which tumors need to grow and spread.

This study is sponsored by OncoMed Pharmaceuticals, which is referred to as OncoMed or the Sponsor in this consent form.


Clinical Trial Description

This is an open-label, Phase 1b dose escalation and expansion study of demcizumab plus pembrolizumab designed to evaluate the safety, efficacy and pharmacokinetics of demcizumab in combination with pembrolizumab in patients with advanced or metastatic solid tumors. This study consists of a screening period, a treatment period and a post-treatment follow up period in which patients will be followed for survival for approximately 12 months. Patients will be enrolled in two stages: a dose-escalation stage and an expansion phase.

Approximately 42 patients will be enrolled in this study at approximately 10 study centers in the United States (U.S) and Europe. ;


Study Design


Related Conditions & MeSH terms

  • Locally Advanced or Metastatic Solid Tumors
  • Neoplasms

NCT number NCT02722954
Study type Interventional
Source Mereo BioPharma
Contact
Status Completed
Phase Phase 1
Start date January 2016
Completion date May 19, 2017

See also
  Status Clinical Trial Phase
Terminated NCT04564417 - First-In-Human (FIH) Study of W0180 as Single Agent and in Combination With Pembrolizumab in Adults With Locally Advanced or Metastatic Solid Tumors Phase 1
Recruiting NCT04511845 - A Dose-Escalation Study of SPYK04 in Patients With Locally Advanced or Metastatic Solid Tumors (With Expansion). Phase 1
Active, not recruiting NCT04128423 - Study of AMV564 in Subjects With Advanced Solid Tumors Phase 1
Recruiting NCT05012618 - A Dose-escalation Study of LUNA18 in Patients With Locally Advanced or Metastatic Solid Tumors (With Expansion). Phase 1
Recruiting NCT05581004 - A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7502175 as a Single Agent and in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Solid Tumors Phase 1
Completed NCT03736850 - Study of CS3006 in Subjects With Locally Advanced or Metastatic Solid Tumors Phase 1
Recruiting NCT05137275 - Study of Anti-5T4 CAR-raNK Cell Therapy in Locally Advanced or Metastatic Solid Tumors Early Phase 1
Completed NCT01021748 - A Combination Therapy Study of MK-2206 and AZD6244 in Participants With Advanced Solid Tumors (MK-2206-010) Phase 1
Completed NCT01713036 - Oral Bioavailability and Mass Balance Trial With Pimasertib Phase 1
Recruiting NCT05116709 - Assessment of Safety and Preliminary Clinical Efficacy With BAT6005 in Advanced Malignant Solid Tumors Phase 1
Recruiting NCT05102214 - HLX301 (TIGIT×PDL1 Bispecific) in Patients With Locally Advanced or Metastatic Solid Tumors Phase 1/Phase 2
Completed NCT03478995 - Study to Evaluate Safety and Tolerability of GX-I7 in Patients With Locally Advanced or Metastatic Solid Tumors Phase 1
Not yet recruiting NCT06293651 - Clinical Trial to Investigate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of DA-4505 as a Single Agent and in Combination With Pembrolizumab in Adult Patients With Locally Advanced or Metastatic Solid Tumors Phase 1/Phase 2
Recruiting NCT06328439 - A Study to Evaluate ANS014004 in Subjects With Locally Advanced or Metastatic Solid Tumors Phase 1
Active, not recruiting NCT05830539 - IN10018 Combination Therapy in Previously-treated Locally Advanced or Metastatic Solid Tumor Patients Phase 1/Phase 2
Recruiting NCT05205109 - A Study to Assess the Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of ATG 037 Monotherapy and Combination Therapy With Pembrolizumab in Patients With Advanced Solid Tumors Phase 1
Active, not recruiting NCT05360381 - HLX35(EGFR×4-1BB Bispecific) in Patients With Advanced or Metastatic Solid Tumors Phase 1
Completed NCT03150810 - Study to Assess Safety, Tolerability and Clinical Activity of BGB-290 in Combination With Temozolomide (TMZ) in Participants With Locally Advanced or Metastatic Solid Tumors Phase 1/Phase 2
Recruiting NCT05957471 - Study of BC3195 Monotherapy in Patients With Advanced Solid Tumors Phase 1
Terminated NCT03565991 - Javelin BRCA/ATM: Avelumab Plus Talazoparib in Patients With BRCA or ATM Mutant Solid Tumors Phase 2