Locally Advanced or Metastatic Solid Tumors Clinical Trial
Official title:
A Phase 1b, Open-Label, Dose Escalation and Expansion Study of Demcizumab Plus Pembrolizumab in Patients With Locally Advanced or Metastatic Solid Tumors
The purpose of this study is to test the efficacy and safety of an experimental drug,
demcizumab, when given in combination with pembrolizumab. Demcizumab is a humanized
monoclonal antibody and was developed to target cancer stem cells. Demcizumab may block the
growth of cancer stem cells, the remaining cancer cells, and it may also impair the
productive growth of new blood vessels, which tumors need to grow and spread.
This study is sponsored by OncoMed Pharmaceuticals, which is referred to as OncoMed or the
Sponsor in this consent form.
This is an open-label, Phase 1b dose escalation and expansion study of demcizumab plus
pembrolizumab designed to evaluate the safety, efficacy and pharmacokinetics of demcizumab in
combination with pembrolizumab in patients with advanced or metastatic solid tumors. This
study consists of a screening period, a treatment period and a post-treatment follow up
period in which patients will be followed for survival for approximately 12 months. Patients
will be enrolled in two stages: a dose-escalation stage and an expansion phase.
Approximately 42 patients will be enrolled in this study at approximately 10 study centers in
the United States (U.S) and Europe.
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Status | Clinical Trial | Phase | |
---|---|---|---|
Terminated |
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