Episodic or Chronic Cluster Headache Clinical Trial
Official title:
Cluster Headache and SPINK-1 Gene
Cluster headache (CH) is a rare, excruciating primary headache disorder. A genetic basis has
been suggested by family and twin studies, but the mode of transmission seems to vary and
the amount of heritability is unclear.
The number of genetic association studies investigating variants implicated in the
pathophysiology of CH is limited. The HCRTR2 1246G > A and the ADH4 925A > G polymorphisms
have been associated with CH. The former has been confirmed and may affect the hypothalamic
hypocretin system. The aim of the present study was to investigate the possible link between
SPINK 1 gene and cluster headache.
| Status | Completed |
| Enrollment | 42 |
| Est. completion date | July 2015 |
| Est. primary completion date | November 2013 |
| Accepts healthy volunteers | Accepts Healthy Volunteers |
| Gender | Both |
| Age group | 18 Years and older |
| Eligibility |
Inclusion Criteria: - People aged 18 or over - Patient consulting in Marseille's or Nice's Pain departments - Patient agreeing to participate to the research study - Patient with health insurance Exclusion Criteria: - People aged under 18 - Patient refusing to participate to the research study - Patient with deprivation of liberty |
Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Screening
| Country | Name | City | State |
|---|---|---|---|
| France | APHM | Marseille |
| Lead Sponsor | Collaborator |
|---|---|
| Assistance Publique Hopitaux De Marseille |
France,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | SPINK1 genotyping | 2 months | No |