Polymorphisms of the Thiazide's Receptor Gene SLC12A3 and Development of Hyponatremia

Thiazide Diuretics Induced Hyponatremia Clinical Trial

Official title:

Polymorphisms of the Thiazide's Receptor Gene SLC12A3 and Development of Hyponatremia

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01346891
• Other study ID #: 1579
• Status: Completed
• Phase: N/A
• First received: May 2, 2011
• Last updated: July 5, 2011
• Start date: July 2010

Study information

• Verified date: July 2010
• Source: Hospital Italiano de Buenos Aires
• Contact: n/a
• Is FDA regulated: No
• Health authority: Argentina: Administracion Nacional de Medicamentos, Alimentos y Tecnologia Medica
• Study type: Observational

Clinical Trial Summary

The purpose of this study is to detect if there are any differences in the coding region of SLC12A3 gene in individuals who have had hyponatremia associated to the use of thiazides, and those thiazides consumers without hyponatremia that have demonstrated good tolerance to the drug.

Description:

This is a Case Control study to compare the coding region of SLC12A3 gene in individuals who have had hyponatremia associated to the use of thiazides, and those thiazides consumers without hyponatremia that have demonstrated good tolerance to the drug.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 40
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 21 Years and older

Eligibility

Inclusion Criteria:

1. Patients older than 21 years, belonging to one of the following groups:

1. Patients who have had Thiazide induced hyponatremia with serum sodium lower than 125 meq/L included in the Institutional Registry of Hyponatremia (Cases)

2. Patients with good tolerance to chronic treatment with Thiazides tha never had associated hyponatremia (Controls)

2. Patients with normal serum sodium measurements before the start of the Thiazides

Exclusion Criteria:

1. Refusal to participate or to the informed consent process

2. Unclear cause of hyponatremia, or other hyponatremia cause concomitant to Thiazide diuretics

3. Patients related to other individuals already included in the study

Study Design

Observational Model: Case Control, Time Perspective: Retrospective

Related Conditions & MeSH terms

• Hyponatremia
• Thiazide Diuretics Induced Hyponatremia

Locations

Country	Name	City	State
Argentina	Hospital Italiano de Buenos Aires	Capital Federal

Sponsors (2)

Lead Sponsor	Collaborator
Hospital Italiano de Buenos Aires	Sociedad Argentina de Hipertension Arterial (SAHA)

Country where clinical trial is conducted

Argentina,