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Effects of Denosumab on Bone Microarchitecture After Total Knee Arthroplasty

Osteoarthritis, Knee Clinical Trial

Official title:
Single Dose Subcutaneous Injections of Denosumab for Patients Underwent Cemented Total Knee Arthroplasty. A Randomized Controlled Study on the Effects on Bone Microarchitecture, Skeletal Muscle, Cartilage and Synovium

Clinical Trial Summary

This study evaluates single dose of Denosumab in decreasing systemic and periprosthetic bone resorption after Total Knee Arthroplasty compared to placebo in 60 patients (30 placebo and 30 Denosumab) within 2 months after surgery. This study also evaluates the anti-RANKL effect of single dose of Denosumab in serum, skeletal muscle, synovium, fat, and cartilage.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05559268
Study type Interventional
Source The Affiliated Hospital of Qingdao University
Contact Shuai Xiang, M.D,
Phone +86-18661809209
Email 15169093669@163.com
Status Not yet recruiting
Phase Phase 4
Start date October 1, 2022
Completion date December 31, 2023
View Details
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