Influence of Adipocytokines in Osteoarthritis

Osteoarthritis, Knee Clinical Trial

Official title:

Adipocytokines Influence on Clinical and Ultrasonographic Inflammatory Activity in Patients With Knee Osteoarthritis

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT01906281
• Other study ID #: Joan01
• Status: Recruiting
• Phase: N/A
• First received: July 5, 2013
• Last updated: November 7, 2013
• Start date: July 2013
• Est. completion date: December 2014

Study information

• Verified date: November 2013
• Source: Hospital Parc Taulí, Sabadell
• Contact: Joan Calvet, Dr
• Phone: 0034 937231010
• Email: joan.calvet.fontova[@]gmail.com
• Is FDA regulated: No
• Health authority: Spain: Comité Ético de Investigación Clínica
• Study type: Observational

Clinical Trial Summary

Adipocytokines play an important role in joint inflammation in patients with knee osteoarthritis as measured by ultrasound and high sensitivity protein-C reactive. Adipocytokines could be the link between osteoarthritis and cardiovascular risk factors more prevalent in these patients.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 105
• Est. completion date: December 2014
• Est. primary completion date: November 2014
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 50 Years to 80 Years

Eligibility

Inclusion Criteria:

• Patients over 50 years old with symptomatic knee osteoarthritis.

Exclusion Criteria:

• Patients with secondary osteoarthritis of the knee

• Any other rheumatologic condition.

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Cardiovascular Risk Factors
• Endocrine System Diseases
• Osteoarthritis
• Osteoarthritis, Knee

Intervention

Other:
• Blood analyse, arthrocentesis, ultrasound examination

Locations

Country	Name	City	State
Spain	Hospital Parc Tauli	Sabadell	Barcelona
Spain	Hospital Parc Tauli Sabadell	Sabadell	Barcelona

Sponsors (1)

Lead Sponsor	Collaborator
Hospital Parc Taulí, Sabadell

Country where clinical trial is conducted

Spain, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	adipocytokine level	We will determine the adipocytokine level at the end of inclusion period between 12-18 months	18 months	No
Secondary	Ultrasound inflammatory exploration of the knee	we evaluate the presence of synovial fluid with ultrasound evaluation in the visit of the patient. Ultrasound evaluation will be performed by two Rheumatologists.	18 months	No
Secondary	Ultrasound of carotid artery	We will evaluate patients with ultrasound exploration in order to describe the presence of atheromatous disease in the visit of the patient	18 months	No
Secondary	Cardiovascular risk factors	We evaluate the prevalence of cardiovascular risk factors in the symptomatic knee osteoarthritis patients, and the relationship with adipocytokines. We will evaluate blood analyse levels of cholesterol, glycemia.	18months	No