Oral Health — Quaternary Ammonium Methacryloxy Silicate-containing Acrylic Resin
Citation(s)
Addy M, Shaw WC, Hansford P, Hopkins M The effect of orthodontic appliances on the distribution of Candida and plaque in adolescents. Br J Orthod. 1982 Jul;9(3):158-63.
Al-Ahmad A, Wunder A, Auschill TM, Follo M, Braun G, Hellwig E, Arweiler NB The in vivo dynamics of Streptococcus spp., Actinomyces naeslundii, Fusobacterium nucleatum and Veillonella spp. in dental plaque biofilm as analysed by five-colour multiplex fluorescence in situ hybridization. J Med Microbiol. 2007 May;56(Pt 5):681-7.
Bjerklin K, Gärskog B, Rönnerman A Proximal caries increment in connection with orthodontic treatment with removable appliances. Br J Orthod. 1983 Jan;10(1):21-4.
Carmona-Ribeiro AM, de Melo Carrasco LD Cationic antimicrobial polymers and their assemblies. Int J Mol Sci. 2013 May 10;14(5):9906-46. doi: 10.3390/ijms14059906. Review.
Chang CS, Al-Awadi S, Ready D, Noar J An assessment of the effectiveness of mechanical and chemical cleaning of Essix orthodontic retainer. J Orthod. 2014 Jun;41(2):110-7. doi: 10.1179/1465313313Y.0000000088. Epub 2014 Feb 17.
Chávez de Paz LE Development of a multispecies biofilm community by four root canal bacteria. J Endod. 2012 Mar;38(3):318-23. doi: 10.1016/j.joen.2011.11.008. Epub 2012 Jan 5.
Coulthwaite L, Verran J Potential pathogenic aspects of denture plaque. Br J Biomed Sci. 2007;64(4):180-9. Review.
Hibino K, Wong RW, Hägg U, Samaranayake LP The effects of orthodontic appliances on Candida in the human mouth. Int J Paediatr Dent. 2009 Sep;19(5):301-8. doi: 10.1111/j.1365-263X.2009.00988.x. Epub 2009 Apr 16. Review.
Kenawy el-R, Worley SD, Broughton R The chemistry and applications of antimicrobial polymers: a state-of-the-art review. Biomacromolecules. 2007 May;8(5):1359-84. Epub 2007 Apr 11. Review.
Lesaffre E, Philstrom B, Needleman I, Worthington H The design and analysis of split-mouth studies: what statisticians and clinicians should know. Stat Med. 2009 Dec 10;28(28):3470-82. doi: 10.1002/sim.3634.
Pandis N, Walsh T, Polychronopoulou A, Katsaros C, Eliades T Split-mouth designs in orthodontics: an overview with applications to orthodontic clinical trials. Eur J Orthod. 2013 Dec;35(6):783-9. doi: 10.1093/ejo/cjs108. Epub 2013 Feb 1. Review.
Patel A, Burden DJ, Sandler J Medical disorders and orthodontics. J Orthod. 2009 Dec;36 Suppl:1-21. doi: 10.1179/14653120723346. Review.
Pathak AK, Sharma DS Biofilm associated microorganisms on removable oral orthodontic appliances in children in the mixed dentition. J Clin Pediatr Dent. 2013 Spring;37(3):335-9.
Raj PA, Dentino AR Denture polymers with antimicrobial properties: a review of the development and current status of anionic poly(methyl methacrylate) polymers. Future Med Chem. 2013 Sep;5(14):1635-45. doi: 10.4155/fmc.13.145. Review.
Shu M, Wong L, Miller JH, Sissons CH Development of multi-species consortia biofilms of oral bacteria as an enamel and root caries model system. Arch Oral Biol. 2000 Jan;45(1):27-40.
Vento-Zahra E, De Wever B, Decelis S, Mallia K, Camilleri S Randomized, double-blind, placebo-controlled trial to test the efficacy of nitradine tablets in maxillary removable orthodontic appliance patients. Quintessence Int. 2011 Jan;42(1):37-43.
Verran J Malodour in denture wearers: an ill-defined problem. Oral Dis. 2005;11 Suppl 1:24-8. Review.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
