Effect of Opioids on Ventilation in Children With Obstructive Sleep Apnea

Status Completed

Clinical Trial Summary

The sole objective in this study is to evaluate if routine amounts of opioids given for tonsillectomy in children have greater amounts of respiratory depression in children with documented obstructive sleep apnea when compared with patients that do not have obstructive sleep apnea

Clinical Trial Description

Ventilatory suppression in children following opioid administration is of obvious concern, especially following routine surgical procedures (i.e. adenotonsillectomy). It is thought that patients with obstructive sleep apnea (OSA) have increased sensitivity to opioids, and especially in opioid naïve patients. Recent evidence in adults suggests that patients with moderate to severe OSA may not predispose patients to increased opioid sensitivity in the form of respiratory depression when compared with patients that do not have OSA. It is well known that OSA in children is significantly different from OSA in adults (e.g. gender predilection, central vs. peripheral causation). The manifestation and etiologies are very different in pediatric OSA making it a vastly different disease process. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03938259
Study type	Observational [Patient Registry]
Source	Baylor College of Medicine
Contact
Status	Completed
Phase
Start date	July 1, 2019
Completion date	August 30, 2020

View Details

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