Obsessive-Complusive Disorder Clinical Trial
Official title:
Analysis of Visual-Motor Task Electrophysiological Activity During Deep Brain Stimulation for Treatment-Resistant Movement Disorders
Objective
The objective of this pilot study is to characterize the abnormal neuronal firing patterns of
basal ganglia neurons and those in the premotor cortex in patients with treatment-resistant
movement disorders undergoing deep brain stimulation (DBS) surgery.
Study population
Fifteen adult patients with treatment-resistant movement disorders who are undergoing deep
brain stimulation surgery at Suburban Hospital, Bethesda, Maryland, will be studied.
Design
This is a physiology study of treatment-resistant movement disorder patients who have been
scheduled for implantation of a deep brain stimulation device into the Nucleus accumbens.
Prior to surgery, patients will learn a rewarded visual-motor task and undergo
magnetoencephalography. The task will be repeated during DBS surgery, with collection of
information on electrical activity including single neuronal unit and local field potentials.
The task and MEG will be repeated 3-4 months after surgery. The collected data will be
analyzed for coherence patterns during rest and rewarded movements.
Outcome measures
We plan to characterize and quantify the oscillatory activity present in motor circuits of
treatment-resistant movement disorder patients during rewarded visually guided movements. We
hypothesize that during visually guided movements, neuronal coherence will be significantly
increased relative to resting periods. Thus, by better understanding the alteration in
oscillatory patterns in these patients, we hope to develop better DBS stimulation paradigms
in order to better treat this disease in the future.
Objective:
The objective of this pilot study is to characterize the abnormal neuronal firing patterns of
basal ganglia and thalamic neurons and those in the premotor cortex in patients with
treatment-resistant movement disorders undergoing deep brain stimulation (DBS) surgery.
Neuronal activity will be studied in a decision-making task guided by reward. Secondary
objectives will involve study of how activity in the brain is modulated in such a task and
how DBS can influence the cerebral activity related to decision-making.
Study population:
Fifteen adult patients with treatment-resistant movement disorders (Essential tremor or
Parkinson s disease) who are undergoing deep brain stimulation surgery at Suburban Hospital,
Bethesda, Maryland, will be studied.
Design:
This is a physiology study of medically refractory patients who have been scheduled for
implantation of a deep brain stimulation device into basal ganglia or thalamic structures.
Prior to surgery, patients will learn a rewarded visual-motor task and undergo
magnetoencephalography (MEG). The task will be repeated during DBS surgery, with collection
of information on electrical activity including single neuronal unit and local field
potentials. The task and MEG will be repeated 3 and 6 months after surgery.
Outcome measures:
The collected data will be analyzed for coherence patterns during rest and rewarded
movements. We plan to characterize and quantify the oscillatory activity present in motor
circuits of patients during rewarded visually guided movements. We hypothesize that during
visually guided movements, neuronal coherence will be significantly increased relative to
resting periods. Activity during surgery will be compared with MEG recordings in the same
task both before and after surgery. By understanding the alteration in oscillatory patterns
in these patients, we hope to improve DBS stimulation paradigms in order to optimize
treatment protocols.
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