Effects of Exercise Mode on Cardiac Fat and Function

Obesity Clinical Trial

Official title:

Effects of Exercise Mode on Cardiac Fat and Function

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT03297333
• Other study ID #: 16-1208-4C-1
• Status: Terminated
• Phase: N/A
• Start date: October 1, 2017
• Est. completion date: March 16, 2020

Study information

• Verified date: July 2019
• Source: Southern Illinois University Edwardsville
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The overall goal of this project is to study the effects of exercise energy expenditure matched vigorous dynamic resistance training and aerobic training on cardiac fat, and its relationship to cardiac function and geometry using cardiac Magnetic Resonance Imaging.

Description:

Exercise-induced weight-loss is one of the most common strategies for reducing excess fat in overweight and obese individuals. Although vigorous intensity may be more favorable promoting positive cardiac adaptations compared to low-moderate intensity, evidence of the positive effects of different exercise modes needs to be explored to allow for realistic comparisons with other strategies. Research using cardiac Magnetic Resonance Imaging that compares the effects of different modes of exercise - matched by exercise energy expenditure - on epicardial adipose tissue and paracardial adipose tissue, and how these interventions modify cardiac function and geometry have not been previously explored in obesity.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 18
• Est. completion date: March 16, 2020
• Est. primary completion date: March 16, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 18 Years to 35 Years

Eligibility

Inclusion Criteria:

• Sedentary

• Caucasian

• BMI >30 kg/m2 and < 39.9 kg/m2

Exclusion Criteria:

• Known cardiovascular, metabolic, pulmonary disease or conditions

• Muscular-skeletal injuries

• Taking medications that affect endocrine or cardiovascular function

• Hypertension

• Being engaged in low intensity strength training more than two times per week or moderate-high intensity of any type of frequency

• Being pregnant

• Cigarette smoking

• Having non-removable pieces or devices incompatible with DXA and CMR assessment.

Related Conditions & MeSH terms

• Obesity

Intervention

Other:
• Resistance training
The resistance training group
• Aerobic interval training
The aerobic interval training group

Locations

Country	Name	City	State
United States	Southern Illinois University of Edwardsville	Edwardsville	Illinois

Sponsors (1)

Lead Sponsor	Collaborator
Southern Illinois University Edwardsville

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Changes in Epicardial adipose tissue (EAT)	EAT will be measured using cardiac Magnetic Resonance	2 assessment points: at baseline and week 4
Primary	Changes in Vascular Health	Atrial stiffness will be measured using a pulse wave analysis	2 assessment points: at baseline and week 4
Secondary	Changes in Paracardial adipose tissue (PAT)	PAT will be measured using cardiac Magnetic Resonance	2 assessment points: at baseline and week 4
Secondary	Changes in Body Composition	Body composition will be measured using dual-energy x-ray absorptiometry	2 assessment points: at baseline and week 4
Secondary	Changes in Cardiorespiratory Function	Cardiorespiratory Function will be measured on a treadmill with a metabolic cart	2 assessment points: at baseline and week 4
Secondary	Changes in Muscular Strength	Muscular Strength will be assessed by 1 repetition maximum (1RM) test	2 assessment points: at baseline and week 4