Indole-3-Carbinol Effects on Estrogen Metabolism

Obesity Clinical Trial

Official title:

Effects of Dietary Indole-3-Carbinol on Estrogen Metabolites Across a Wide Range of Body Mass Index: Implications for the Prevention of Endometrial Cancer in Obese Women

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT00988845
• Other study ID #: H-2009-0093
• Secondary ID: CC09709A532800SM
• Status: Terminated
• Phase: Phase 2
• Start date: September 2009
• Est. completion date: January 2014

Study information

• Verified date: April 2015
• Source: University of Wisconsin, Madison
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study will test a dietary supplement, indole-3-carbinol, for improving the estrogen profile in women across a range of body mass index.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 38
• Est. completion date: January 2014
• Est. primary completion date: July 2010
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 30 Years to 50 Years

Eligibility

Inclusion Criteria:

• woman aged from 30 - 50 years

• regular menstrual cycle

Exclusion Criteria:

• taking hormone replacement or hormonal contraception

• thyroid disorder

• uncontrolled asthma

• BMI under 18.5

• allergy to cruciferous vegetables

Related Conditions & MeSH terms

• Obesity

Intervention

Dietary Supplement:
• Indole-3-carbinol
200 mg bid po X 8 weeks

Locations

Country	Name	City	State
United States	University of Wisconsin	Madison	Wisconsin

Sponsors (1)

Lead Sponsor	Collaborator
University of Wisconsin, Madison

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in urinary 2/16-hydroxyestrone ratio		8 weeks