Non Small Cell Lung Cancer Clinical Trial
Official title:
Development of AImmune Technology as a Bioinformatic Component of Diagnostic Tests Used in Cancer Immunotherapy
The goal of the project is to develop and validate A.I.mmune technology. It performs complex
analyses of patients' tumor and immune system state using data derived from next-generation
sequencing of tumor and healthy tissue to identify cancer neoantigens, which are likely to
elicit an immune response.
A key challenge to be solved using the technology is to predict for each patient which
neoepitopes are not only likely to bind to HLA or be presented on the tumor cell surface, but
also will be recognized by the T-cell receptor and create the immunogenic response. The
presence of such epitopes is required for immunotherapy by immune checkpoint inhibition to
have an effect on the disease. Knowledge of those epitopes enables therapeutic strategies to
boost the immune response by designing personalized cancer vaccines and adoptive cell
therapies.
The samples and data collected in this clinical study will be used for clinical validation of
A.I.mmune technology. For all patients treated with immunotherapy (using anti-PD1 / anti-PDL1
and / or anti-CTLA-4 antibodies) peripheral blood samples (PBMC) and biopsy (FFPE) collection
will be performed before treatment. Samples will be sequenced by next-generation sequencing
platform. In parallel, the investigators will also collect samples of stool (one sample
before the start of immunotherapy) and follow-up information of responses to treatment.
n/a
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