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PARP Inhibitor With 177Lu-DOTA-Octreotate PRRT in Patients With Neuroendocrine Tumours — PARLuNET  

Neuroendocrine Tumors Clinical Trial

Official title:
Phase 1 Trial of PARP Inhibitor Combined With 177Lu-DOTA-Octreotate Peptide Receptor Radionuclide Therapy (PRRT) in Patients With Metastatic NeuroEndocrine Tumor

Clinical Trial Summary

This phase 1 dose-escalation study is designed to evaluate the safety and tolerability of talazoparib in combination with 177Lu-DOTA-Octreotate peptide receptor radionuclide therapy (PRRT) in patients with metastatic pancreatic or midgut neuroendocrine tumour (NET).

Clinical Trial Description

This phase 1, single arm, single centre study is designed to evaluate the safety and tolerability of talazoparib in combination with 177Lu-DOTA-Octreotate in patients with metastatic NET. Patients will receive 1 cycle of 177Lu-DOTA-Octreotate alone followed by 3 cycles of 177Lu-DOTA-Octreotate combined with 5 days of talazoparib. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05053854
Study type Interventional
Source Peter MacCallum Cancer Centre, Australia
Contact Grace Kong
Phone 85595000
Email NMResearch@petermac.org
Status Recruiting
Phase Phase 1
Start date December 8, 2021
Completion date December 31, 2025
View Details
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