Neuroblastoma Clinical Trial
Official title:
ROR1 as a Novel Target for Neuroblastoma
RATIONALE: Studying samples of tissue and bone marrow from patients with cancer in the
laboratory may help doctors learn more about changes that occur in DNA and identify
biomarkers related to cancer.
PURPOSE: This research study studies biomarkers in samples from young patients with
neuroblastoma.
OBJECTIVES:
Primary
- To analyze the expression of ROR1 on the surface of primary neuroblastoma cells.
- To investigate the therapeutic potential of anti-ROR1 monoclonal antibodies (mAbs),
bispecific antibodies, and immunotoxins in in vitro and in vivo models of
neuroblastoma.
OUTLINE: Archived bone marrow and tumor tissue samples are analyzed for ROR1 expression by
flow cytometry, western blotting, qPCR, and IHC.
;
Observational Model: Case-Only, Time Perspective: Retrospective
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