Determinants of Physical Activity Level in Pediatric Oncological Patients Treated With Cardiotoxic Therapy - a Study Protocol

Neoplasms Clinical Trial

Official title: Determinants of Physical Activity Level in Pediatric Oncological Patients Treated With Cardiotoxic Therapy - a Study Protocol

Status Not yet recruiting

Clinical Trial Summary

Cancer treatment in children is very effective, but unfortunately has side effects - unwanted, bad impact. Some drugs that are given during cancer treatment, in addition to their good effect, can affect the heart badly and can lower the physical activity tolerance, such as climbing stairs, fast walking, running, exercise. Physical activity is very important for the proper growth and development of children and future adults. Heart is an important organ pumping the blood around the body and its good function is one of the key determinants of physical activity level in humans.

The goal of this study is to is to find what impacts physical activity level in children treated for cancer with treatment methods that may be toxic to the heart to learn about influence of this treatment on the physical activity level of these children.

The main questions this study aims to answer are:

• Do children after cancer treatment involving heart toxic treatment methods present lower level of daily physical activity in comparison to the children treated with different methods?

• Is the level of physical activity related to the heart toxic treatment, or other such as exercise capacity (measured physical strength on the treadmill or standing bike), quality of life, lifestyle, social and demographic factors, body type as well as the knowledge about positive impact of physical activity, efficacy, and motivation to physical activity?

Participants will:

• fill in the questionnaire,

• perform an exercise test on the treadmill or standing bike (to measure exercise capacity),

• perform ALPHA test (physical fitness test) consisting of some simple exercise like jumping, running etc.,

• be measured and weighted,

• be measured by the hand-grip test with the hand dynamometer machine,

• wear activity-tracker band for 14 days,

• be examined by the ultrasound of the heart (echocardiography).

Researchers will compare 144 children treated with heart toxic methods for cancer to 144 children treated for cancer with non-toxic methods. The children will be aged 8-18 years old and will be 1-5 years after treatment for cancer.

The researchers believe that finding what influences physical activity level in children after cancer treatment with heart toxic methods may

• make the therapy for cancer in children better, with less side effects

• by that, can cause increase in the physical activity and ensure better growth and health for these children in the future.

Clinical Trial Description

n/a

Related Conditions & MeSH terms

• Neoplasms

• NCT number: NCT06256068
• Study type: Observational
• Source: Medical University of Warsaw
• Contact: Julia Haponiuk-Skwarlinska, MD
• Phone: 515400472
• Email: julia.haponiuk-skwarlinska@wum.edu.pl
• Status: Not yet recruiting
• Start date: February 5, 2024
• Completion date: June 30, 2026