Myopia — Comparison of Clinical Outcomes of Small-incision Lenticule Extraction (SMILE) Between Different Cap Thickness.
Citation(s)
Damgaard IB, Ivarsen A, Hjortdal J Refractive Correction and Biomechanical Strength Following SMILE With a 110- or 160-µm Cap Thickness, Evaluated Ex Vivo by Inflation Test. Invest Ophthalmol Vis Sci. 2018 Apr 1;59(5):1836-1843. doi: 10.1167/iovs.17-23675.
El-Massry AA, Goweida MB, Shama Ael-S, Elkhawaga MH, Abdalla MF Contralateral Eye Comparison Between Femtosecond Small Incision Intrastromal Lenticule Extraction at Depths of 100 and 160 µm. Cornea. 2015 Oct;34(10):1272-5. doi: 10.1097/ICO.0000000000000571.
Fernández J, Rodríguez-Vallejo M, Martínez J, Tauste A, Piñero DP Corneal biomechanics after laser refractive surgery: Unmasking differences between techniques. J Cataract Refract Surg. 2018 Mar;44(3):390-398. doi: 10.1016/j.jcrs.2017.10.054. Epub 2018 Mar 31. Review.
He M, Wang W, Ding H, Zhong X Comparison of Two Cap Thickness in Small Incision Lenticule Extraction: 100µm versus 160µm. PLoS One. 2016 Sep 21;11(9):e0163259. doi: 10.1371/journal.pone.0163259. eCollection 2016.
Liu M, Zhou Y, Wu X, Ye T, Liu Q Comparison of 120- and 140-µm SMILE Cap Thickness Results in Eyes With Thick Corneas. Cornea. 2016 Oct;35(10):1308-14. doi: 10.1097/ICO.0000000000000924.
Weng S, Liu M, Yang X, Liu F, Zhou Y, Lin H, Liu Q Evaluation of Human Corneal Lenticule Quality After SMILE With Different Cap Thicknesses Using Scanning Electron Microscopy. Cornea. 2018 Jan;37(1):59-65. doi: 10.1097/ICO.0000000000001404.
Comparison of Clinical Outcomes of Small-incision Lenticule Extraction (SMILE) Between Different Cap Thickness.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
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Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
