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NCT00412672 Clinical Trial

Protective Effect of Coronary Collaterals on Infarct Size in Patients With Acute Myocardial Infarction

Myocardial Infarction Clinical Trial

Official title:
Protective Effect of Coronary Collaterals on Infarct Size in Patients With Acute Myocardial Infarction

Clinical Trial Details — Status: Withdrawn

Administrative data
NCT number NCT00412672
Other study ID # 37/01
Secondary ID
Status Withdrawn
Phase N/A
First received December 15, 2006
Last updated June 15, 2015
Start date July 2010

Study information
Verified date June 2015
Source University Hospital Inselspital, Berne
Contact n/a
Is FDA regulated No
Health authority Switzerland: Swissmedic
Study type Observational

Clinical Trial Summary

The hypothesis of the current proposal is that collateral flow is an important determinant of myocardial protection during an ischemic event. Increased collateral flow for any given area at risk will decrease the myocardial damage caused by the occlusion of the infarct related epicardial artery.

It is further hypothesized that myocardial salvage provided by collateral flow will decrease infarct size and this in turn will decrease LV dilatation post-myocardial infarction.

Description:

The hypothesis of the current proposal is that collateral flow is an important determinant of myocardial protection during an ischemic event. Increased collateral flow for any given area at risk will decrease the myocardial damage caused by the occlusion of the infarct related epicardial artery.

It is further hypothesized that myocardial salvage provided by collateral flow will decrease infarct size and this in turn will decrease LV dilatation post-myocardial infarction.

The two primary endpoints are infarct size as assessed by increase of biochemical cardiac markers and coronary collateral perfusion index (CPI) as obtained by transthoracic MCE.

Extent of LV remodelling, i.e., LV dilatation as assessed by serial assessment of LV dimension by LV angiogram and/or echocardiography, respectively.

Recruitment information / eligibility
Status Withdrawn
Enrollment 0
Est. completion date
Est. primary completion date
Accepts healthy volunteers No
Gender Both
Age group 18 Years to 80 Years
Eligibility Inclusion Criteria:

- Patients with acute myocardial infarction with electrocardiographic criterion and/or typical history of angina pectoris and planned revascularisation according to the acute myocardial infarction disease management guidelines of the University Hospital Bern. Including both, patients undergoing primary PCI and patients referred for rescue PCI after failed thrombolytic therapy

- Patients > 18 years old of either sex

- Patients who have given informed consent to the study

Exclusion Criteria:

- Patients unable to give informed consent e.g. because of mechanical ventilation

- Patients with cardiogenic shock

- Patients with myocardial infarction secondary to occlusion of a recently revascularized vessel (subacute stent thrombosis)

- Patients with severe arrhythmias

- Patients whose door-to-balloon time exceeds 120 minutes

- Pregnancy

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Locations
Country Name City State
n/a

Sponsors (2)
Lead Sponsor Collaborator
University Hospital Inselspital, Berne Swiss National Science Foundation
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