Mycosis Fungoides Clinical Trial
Official title:
In Vitro Evaluation of Immune Responses in CTCL
This is an in vitro evaluation of cutaneous T-cell lymphoma using patients' blood and tissue to evaluate immune responses related to identified tumor populations and dendritic/CD 8 cells.
This is an in vitro evaluation of cutaneous T-cell lymphoma using patients blood and tissue
to evaluate immune responses related to identified tumor populations and dendritic/ CD 8
cells with the following objectives:
- Objective I: Evaluate the feasibility of the preparation of dendritic cells (DCs), CD8
and Sezary cells (all CD4 positive) in vitro, obtained from the buffy coats or a skin
biopsy from an area with tumor involvement of subjects with cutaneous t-cell lymphoma
(CTCL) and Sezary syndrome (leukemic stage of CTCL) undergoing an approved FDA therapy,
extracorporeal photopheresis (ECP).
- Objective II: Evaluate antigen loading of the DCs.
- Objective III: Test the functional capacities of the DCs derived from CTCL subjects to
overcome immune tolerance to the tumor cells ex-vivo, by using modified Elispot assay
in conjunction with Granzyme B Elispot assay as a measurement of cytotoxicity.
;
Time Perspective: Prospective
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|---|---|---|---|
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