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Movement Disorders clinical trials

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NCT ID: NCT03892798 Completed - Clinical trials for Autism Spectrum Disorder

Database Of Clinical Data For Individuals With Variants In The IRF2BPL Gene

IRF2BPL
Start date: November 27, 2018
Phase:
Study type: Observational [Patient Registry]

This protocol serves as a data collection tool for individuals with variants (missense, nonsense, frameshifts) in the IRF2BPL gene (MIM 611720), which causes Neurodevelopmental Regression, Seizures, Autism and Developmental Delay (NEDAMSS, MIM 618088) and may be involved in other neurodevelopmental presentations. This information will be analyzed to develop a better understanding of the findings and progression of symptoms in individuals with variants in the IRF2BPL gene.

NCT ID: NCT03884231 Completed - Parkinson Disease Clinical Trials

A Post-Market Study Evaluating the Safety of Infinity DBS System With MR Conditional Labeling

Start date: April 10, 2019
Phase:
Study type: Observational

This is a study of subjects with the St. Jude Medical Infinity deep brain stimulation (DBS) system who undergo an MRI imaging procedure. Enrollment may occur before DBS implant, or when an MRI scan is planned in a subject with an existing implant. There will be a follow-up visit one month after the MRI procedure to document any adverse events and verify device functionality.

NCT ID: NCT03775538 Completed - Parkinson Disease Clinical Trials

Safety of CDNF by Brain Infusion in Patients With Parkinson's Disease. Extension to HP-CD-CL-2002 Clinical Study

Start date: July 5, 2018
Phase: Phase 1/Phase 2
Study type: Interventional

This study is an extension to the HP-CD-CL-2002 clinical study. It evaluates the long-term safety and tolerability of CDNF in patients with Parkinson's disease when dosed directly into the brain using an implanted investigational drug delivery system (DDS). Long-term safety of the DDS is also being evaluated. All patients will receive monthly infusions of either mid- or high-dose of CDNF for a period of 6 months.

NCT ID: NCT03756428 Completed - Movement Disorders Clinical Trials

Effects on Plantar Support After Deep Dry Needling in Posterior Tibial Muscle

Start date: December 1, 2018
Phase: N/A
Study type: Interventional

This study aims to analyze the changes in plantar support after the technique of deep dry puncture in the posterior tibial. The data will be analyzed by a baropodometer which will record the possible changes in the footprint. The investigator will perform a pre-intervention measurement and 3 post-intervention measurements (immediately after the intervention, at 24 hours and at 72 hours)

NCT ID: NCT03722212 Completed - Seizures Clinical Trials

Early Diagnosis of the GLUT1 Deficiency Syndrome With a Blood Based Test

METAglut1
Start date: September 24, 2018
Phase: N/A
Study type: Interventional

The study aims at validating the diagnostic performances of the METAglut1, a blood in vitro diagnostic test, for the simple and early diagnosis of the Glut1 deficiency syndrome (Glut1DS, or De Vivo disease). The blood test will be carried out prospectively on patients presenting with a clinical suspicion of Glut1DS, blindly from the reference strategy, which consists in a lumbar puncture for glycorrhachia measurement, completed by a molecular analysis. The study will be conducted in more than 40 centers in France on up to 3,000 patients for 2 years.

NCT ID: NCT03717376 Completed - Parkinson Disease Clinical Trials

Movement Disorders and Early Maladaptive Schemas

SCHEMAF
Start date: February 12, 2019
Phase:
Study type: Observational

Functional neurological disorders (FND) are neurological symptoms that cannot be explained by a lesion or related to an identified dysfunction of the central nervous system. FND are under-diagnosed, although common and highly disabling. Childhood trauma events are found in 30% to 80% of FND patients, and are more common in people with functional neurological disorder than in healthy controls and patient controls. Overall, risks factors, perpetuating factors and maintaining factors have been described in FND, although none of the studies have analysed the prevalence of Early Maladaptive Schemas (EMS) in these patients. EMS, as measured with the Young Schema Questionnaire (YSQ), are proposed to underlie a variety of mental health problems, in particular Personality Disorders. We hypothesize that some of these early maladaptive schemas may participate in the psychopathology and severity of FND. The main outcome of this study is to assess the prevalence of early maladaptive schemas in patients presenting with Functional Movement Disorders in comparison to patients presenting with Parkinson's Disease or Organic Dystonia. The secondary outcomes are to further analyse the underlying relation of these early maladaptive schemas and (i) the severity of the motor symptoms, (ii) anxiety and/or depression, (iii) the occurrence of childhood trauma events in our participants.

NCT ID: NCT03638479 Completed - Parkinson Disease Clinical Trials

Utilizing Smart Devices to Identify New Phenotypical Characteristics in Movement Disorders

Start date: January 8, 2019
Phase:
Study type: Observational

This observational and experimental study seeks to establish a Smart Device System (SDS) to monitor high-resolution handtremor-based data using Smartphones, SmartWatches and Tablets. By doing this, movement data will be analyzed in depth with advanced statistical and Deep-Learning algorithms to identify new clinical phenotypical characteristics Parkinson's Disease and Essential Tremor.

NCT ID: NCT03563807 Completed - Parkinson Disease Clinical Trials

Golf Instruction Versus Tai Chi for People With Parkinson's Disease

Start date: April 23, 2018
Phase: N/A
Study type: Interventional

The purpose of this study is to determine the feasibility and tolerability of golf instruction for participants with moderate to advanced Parkinson's disease (PD). Other forms of exercise have been shown to be beneficial for PD. Golf is a low impact sport that utilizes balance and strength. Currently, there are no data looking at the effects of golf on PD. This pilot study aims to test the effects of golf in the PD patient population, particularly its effect on balance. In this study, we will be comparing group golf instruction to group Tai Chi lessons (the gold standard balance exercise for patients with PD).

NCT ID: NCT03528096 Completed - Clinical trials for Sleep Related Rhythmic Movement Disorder (Disorder)

Vestibular Stimulation Therapy for Rhythmic Movement Disorder

Start date: March 30, 2018
Phase: N/A
Study type: Interventional

This study aims to a) investigate the feasibility of the detection of episodes of RMD using contactless 3D video analysis and customised analysis software and b) the use of vestibular stimulation as a therapy for childhood rhythmic movement disorder.

NCT ID: NCT03503916 Completed - Postural Balance Clinical Trials

The Relation Between Movement Patterns, Balance Performance, Function of the Inner Ear and Falls

Start date: February 27, 2017
Phase:
Study type: Observational

Falls are one of the most common reasons for immobilisation and death in elderly population. This study aims at studying falls among a group of older people. The aim is to study the relation between movement patterns, balance performance, inner ear function and future falls. Senior member will be recruited through the non-profit association "Friskis&Svettis. Measures of movement patterns, balance performance and innear ear function will be measured at baseline. Falls will be monitored through falls diaries, collected every third month during a 12 month period.