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Mood Disorders clinical trials

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NCT ID: NCT04642092 Recruiting - Depression Clinical Trials

Evidence-Based Psychological Treatment for Emotional Disorders Attended in Dominican Primary Care Units (PsicAP)

PsicAP
Start date: August 9, 2021
Phase: N/A
Study type: Interventional

Emotional disorders affect millions of people all over the world. Thousands of Dominicans suffer from depression, anxiety, and other emotional disorders that have negative impact on their lives. Nevertheless, many of them do not receive a proper treatment. The purpose of this study is to describe a pilot project, in which a protocol of evidence-based psychological treatment for emotional disorders, supported by mHealth (mobile health), will be applied on Dominicans who attend Primary Care services. It will be a collaborative program, divided into three phases, and based on cognitive behavioral therapy. The hypothesis of this research is that this protocol is an effective strategy to treat emotional disorders.

NCT ID: NCT04483661 Recruiting - Mood Disorders Clinical Trials

Development of Systems and Precision Medicine - Take Mood Disorder as an Example.

Start date: November 27, 2019
Phase:
Study type: Observational

Precision medicine is to achieve individual optimal health care, given the biological mechanisms, genetic variants, and environmental measurements. Take mood disorder (MD) as an example, we aim to develop systems and precision medicine in Taiwanese population. MD is a very serious and dysfunctional mental disorder. Since MD patients with treatment have high risk of neurocognitive impairment and metabolic disturbances, the therapeutic strategies are of clinical importance. Individual difference of treatment outcome in MD patients would result from genetic variants, environmental factors, and their interactions. Also, the treatment outcome of MD contains multiple dimensions, including improvement of disease severity, neurocognitive function, and optimized medication strategy. However, comprehensive development of approaches to investigate the multiple dimensions of treatment outcome in MD patients is limited. In this three-year proposal, we explore the interactions of genetic variants and environmental factors (represented by psychosocial stress and gut microbiota) driven approaches to develop precision medicine.

NCT ID: NCT04414215 Recruiting - Schizophrenia Clinical Trials

Cognitive Training for Emotion Regulation in Psychotic Disorders

Start date: June 1, 2020
Phase: N/A
Study type: Interventional

The current study examines the efficacy of a cognitive training intervention for improving emotion regulation in psychotic disorders. it is hypothesized that the cognitive training program will enhance prefrontal activation, leading to enhanced emotion regulation.

NCT ID: NCT04354974 Recruiting - Clinical trials for Taking Charge of Cognitive Impairment in Patients With Mood Disorders

Evaluation of a Cognitive Remediation Program for Mood Disorders

ECO-DBP
Start date: October 18, 2019
Phase: N/A
Study type: Interventional

Psychotherapeutic management of cognitive disorders in patients suffering from a mood disorder

NCT ID: NCT04304911 Recruiting - Anxiety Disorders Clinical Trials

UP in Blended Format for Transdiagnostic Treatment of Emotional Disorders in the Spanish National Health System

Start date: March 1, 2023
Phase: N/A
Study type: Interventional

The present randomized, controlled trial will compare the efficacy, cost-effectiveness, and implementation characteristics of a blended intervention based on the Unified Protocol (UP) for transdiagnostic treatment of emotional disorders against the treatment as usual in a sample of patients with emotional disorders in the Spanish National Health System.

NCT ID: NCT04289740 Recruiting - Emotional Disorder Clinical Trials

Transdiagnostic Group Cognitive Behavioral Therapy (PsicAP-A) for Adolescents With Emotional Disorders

PsicAP-A
Start date: April 1, 2022
Phase: N/A
Study type: Interventional

Emotional disorders such as anxiety and depression are highly prevalent during adolescence and associated with functional impairment that commonly extends into adulthood. In the primary care (PC) setting, these disorders are frequently underdiagnosed and undertreated. Objective: To carry out a prospective, randomized controlled trial (RCT) to test the efficacy of a new transdiagnostic cognitive behavioural group therapy (TD-CBT) protocol for adolescents (age 12 to 18 years) compared to group relaxation therapy (RT). Methods: Two-arm, single-blind, RCT (expected N=160) to compare group TD-CBT for emotional disorders to group RT. The group TD-CBT will be administered in seven sessions (90 min/session) over 12 weeks. Psychological assessments will be carried out at baseline, post-treatment, and at months 3, 6, and 12 after treatment. The assessments will include measures of depression, anxiety, somatization, quality of life, disability, and cognitive-emotional factors. The study will be conducted in two PC centres located in Cantabria, Spain. Discussion: This is the first RCT to evaluate the efficacy of group TD-CBT for emotional disorders in adolescents in the PC setting in Spain. If, as expected, the results confirm the superiority of TD-CBT to conventional RT, the widespread implementation of this new approach-based on scientific evidence obtained in a real-world, primary care setting-could improve treatment outcomes and quality of life in adolescents suffering from anxiety or depression.

NCT ID: NCT04284267 Recruiting - Bipolar Disorder Clinical Trials

Neuromodulation for Enhancement of Emotion Regulation in Bipolar Mood Disorders

Start date: March 1, 2021
Phase: N/A
Study type: Interventional

The investigators are conducting this research study to better understand how individuals with bipolar disorder regulate their emotions, and if transcranial magnetic stimulation (TMS) can help improve emotion regulation for individuals with bipolar mood disorders.

NCT ID: NCT04118283 Recruiting - Schizophrenia Clinical Trials

Assessment and Treatment for Chronic Pain in Veterans With Serious Mental Illness

CPSMI
Start date: March 18, 2021
Phase: N/A
Study type: Interventional

Chronic pain has a highly negative impact on Veterans, especially those with serious mental illness (SMI). Chronic pain leads to poorer mental health and physical functioning, and represents a critical obstacle to rehabilitation and recovery. Despite known high prevalence rates of chronic pain in SMI populations, there is little research to: a) evaluate nonpharmacological pain management strategies in this population, and b) examine directional relations between chronic pain and SMI symptoms. This study aims to address research and clinical gaps by: a) testing the feasibility and acceptability of Cognitive Behavioral Therapy for Chronic Pain (CBT-CP) - a VA evidence-based psychotherapy for chronic pain - in Veterans with SMI, and b) better assessing the complex relation between chronic pain and psychiatric symptoms and their impact on functioning. Results from this study will inform us as to whether CBT-CP is feasible to implement, acceptable to Veterans with SMI, and worth examining in its standard or in an optimized form in a larger clinical trial.

NCT ID: NCT04113993 Recruiting - Schizophrenia Clinical Trials

Bazedoxifene -Treatment for Women With Schizophrenia

Start date: October 7, 2019
Phase: Phase 4
Study type: Interventional

To study the effect of adjunctive bazedoxifene - a selective estrogen receptor modulator (SERM) in a double blind, placebo-controlled adjunctive study in the treatment of women with schizophrenia. All patients receive standardized antipsychotic medication.

NCT ID: NCT04099940 Recruiting - Schizophrenia Clinical Trials

Virtual Reality Avatar Therapy for People Hearing Voices

Start date: July 1, 2021
Phase: N/A
Study type: Interventional

Hearing voices is probably the worst form of acoustic hallucinations; which can be experienced as severely disturbing and is influenced by diverse factors including the ability of the individual to influence and control the hallucinatory experience itself. In recent years virtual reality has become a treatment option. In the so-called AVATAR Therapy, patients with schizophrenia and acoustic hallucinations design a visual and auditory recreation (avatar) of the entity to which they attribute their hallucinations. Working with a therapist over the course of several sessions, participants change the avatar from controlling to benevolent. Avatar Therapy involves similar processes to learning and cognitive restructuring, comparable to other psychotherapeutic interventions. The investigators plan to conduct an interventional study using a cross-over design, to compare the feasibility and efficacy of virtual reality avatar therapy for patients with acoustic hallucinations (independent of psychiatric diagnosis) with a cognitive behavioural group therapy aimed to improve social competence.