Risk Factors Contributing to the Development of Microalbuminuria

Microalbuminuria Clinical Trial

Official title: Risk Factors Contributing to the Development of Microalbuminuria Over a 5 Year Period

Status Completed

Clinical Trial Summary

This research project will look at the relationship between baseline variables, and the new onset of microalbuminuria and the response to treatment with an angiotensin receptor blocker, losartan, in a cohort of 246 early hypertensives and normotensives who are being brought back for a 4-5 year follow up visit as part of a continuing project. We hypothesize that the new onset of microalbuminuria is associated with higher blood pressure levels at baseline and 1 year as well as being associated with elevated left ventricular mass index. The rate of new onset microalbuminuria in non-diabetics is not established and this prospective study will provide data.

Clinical Trial Description

The primary objective of this research project is to determine risk factors related to the development of microalbuminuria. The secondary objective is to determine whether uric acid levels at the final visit are correlated with the onset of microalbuminuria. Of participants returning for a 4-5 year follow up visit as part of a continuing project, we will examine the proportion that have developed microalbuminuria. Subjects found to have microalbuminuria will be offered therapy with the ARB losartan and will be followed at three months to determine if there has been a reduction in levels. ;

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Albuminuria
• Microalbuminuria

• NCT number: NCT00572403
• Study type: Observational
• Source: Sunnybrook Health Sciences Centre
• Status: Completed
• Phase: N/A
• Start date: December 2007
• Completion date: April 2008