Metastatic Cancer Clinical Trial
Official title:
A Phase II Pilot Study of Stereotactic Radiosurgery for Limited Malignant Melanoma Brain Metastases
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Stereotactic
radiosurgery may kill more tumor cells.
PURPOSE: Phase II trial to study the effectiveness of radiation therapy followed by
stereotactic radiosurgery in treating patients who have brain metastases from malignant
melanoma.
OBJECTIVES: I. Estimate the 6 month intracranial progression rate and 6 month overall
survival rate in patients with limited brain metastases from malignant melanoma undergoing
whole brain radiotherapy followed by stereotactic radiosurgery boost. II. Evaluate the
qualitative and quantitative toxic effects of this regimen in these patients.
OUTLINE: Patients undergo whole brain radiotherapy 5 days a week for 3 weeks, followed 3-5
weeks later by stereotactic radiosurgery. Patients are followed every 3 months until death.
PROJECTED ACCRUAL: A total of 60 patients will be accrued for this study within 2 years.
;
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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