Metastatic Breast Cancer Clinical Trial
Official title:
Rapid Medical Donation Programme for Breast Cancer to Examine Tumour Heterogeneity
Treatment of breast cancer has traditionally been based on the primary tumour's features in
the breast. Only recently, when cancer returns at other sites, has there been an attempt to
biopsy the metastatic disease and change treatments accordingly. A 'repeat biopsy' can be
technically difficult, painful and, when possible, only represents a small sample of one of
many metastases.
Even when one deposit responds to a new treatment, a neighbouring one may continue to grow.
There is an urgent need to characterise all deposits, particularly the lethal ones which
progress despite all treatments.
This study will enable the comprehensive analysis of the metastatic process and the
evolution of the breast cancer through the course of its treatment. Patients who have
consented during life to donate their tissues for molecular analysis will provide the means
for such an analysis.
Main aims:
- To comprehensively and systematically examine metastatic breast cancer by its detailed
exploratory molecular characterization to elucidate the possible inter- and
intratumoural heterogeneity between the primary tumour and the majority of metastatic
sites.
- To map the natural history of the metastatic breast cancer process
n/a
Time Perspective: Prospective
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