Hepatic Enzymes Clinical Trial
Official title:
Effect of Hyperuricemia Treatment on Hypertension and Metabolic Syndrome
The purpose of this study is to evaluate the influence of hyperuricemia treatment compared with placebo on participants with high risk of hypertension and metabolic syndrome.
Elevated consumption of high fructose corn syrup has lead to an increase of 30% of fructose
intake since the last 20 years. Important data supporting this fact can be reflected on
incidence and prevalence of Metabolic syndrome and hyperuricemia.
A peculiar effect of fructose intake demonstrated in animal models is the development of
elevated uric acid levels; also some studies have found a clear association between
hyperuricemia as an important risk factor for hypertension, diabetes mellitus, chronic
kidney disease and metabolic syndrome.
Taking into account the existing evidence, our clinical research team presents this protocol
as a way to evaluate the effect of uric acid treatment and its relation with Fructose
consumption, metabolic syndrome parameters, hyperuricemia and risk of hypertension.
Confirming evidence with clinical basis may be the initial strategy to create primary
prevention programs to control this health problems affecting Mexican Population.
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Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention