The Effect of Exercise Intervention on the Community's Older Adults

Metabolic Disease Clinical Trial

Official title:

The Effect of Exercise Intervention on the Physical Fitness, Bone Mineral Density and Health-related Quality of Life in the Community's Older Adults

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02936336
• Other study ID #: CMRPG690111-3;CMRPG6A0421-22
• Status: Completed
• Phase: N/A
• Start date: November 2009
• Est. completion date: December 2013

Study information

• Verified date: May 2018
• Source: Chang Gung Memorial Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Osteoporosis is a serious global health problem, second only to cardiovascular disease. Osteoporosis is the most common metabolic bone disease in the elderly population, characterized by loss of bone mineral density (BMD) and continuous destruction of bone microstructure, especially in postmenopausal women. It gives rise to bone fragility and fracture risk. Moreover, as people grow older, falls frequently occur with high severity, and nearly 35% to 45% of persons aged 65 or older fall at least once a year. Osteoporotic fractures increase mortality, morbidity, chronic pain, and the cost of social care and it decreases the quality of life. Here, investigators plan to perform different exercise interventions such as circuit exercise, aerobic dance and Tai Chi on the community's older adults to evaluate whether exercise intervention could improve the bone mineral density, physical fitness, muscle strength or quality of life.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 411
• Est. completion date: December 2013
• Est. primary completion date: December 2013
• Accepts healthy volunteers: No
• Gender: All
• Age group: 45 Years to 85 Years

Eligibility

Inclusion Criteria:

• Being >45 years-of-age,

• Healthy and physically independent.

Exclusion Criteria:

• The exclusion criteria were individuals on hormone replacement therapy and those with cognitive impairment, progressive debilitating conditions, bone fractures, or any medical contraindications to administering the fitness assessment.

Related Conditions & MeSH terms

• Metabolic Disease
• Metabolic Diseases

Intervention

Other:
• exercise
circuit exercise, aerobic dance and Tai Chi exercise

Locations

Country	Name	City	State
Taiwan	Sports Medicine Center, Chang Gung Memorial Hospital	Pizi

Sponsors (1)

Lead Sponsor	Collaborator
Chang Gung Memorial Hospital

Country where clinical trial is conducted

Taiwan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change from baseline bone mineral density	Bone mineral density measurement is measured by dual-energy x-ray absorptiometry (DXA). Measurements are made over the lumbar spine and over the upper part of the hip and the measurement is assessed at Pre-intervention, 3-month, 6-month, 9-month-follow-up.	Pre-intervention, 3-month, 6-month, 9-month-follow-up
Secondary	Change from baseline elbow muscle strength	Extension and flexion of elbow were tested by the HUMAC NORM system (CSMi, Stoughton, MA) with the eccentric/concentric contraction mode at an angular velocity of 60 degrees/s.Isokinetic tests were performed five times for each participant, and each test was separated by a rest period of 3 min.The Muscle strength was present as a peak torque which was normalized to body weight (Unit:Nm/kg). The participants are assessed at Pre-intervention, 3-month, 6-month, 9-month-follow-up.	Pre-intervention, 3-month, 6-month, 9-month-follow-up
Secondary	Change from baseline shoulder muscle strength	Extension and flexion of shoulder were tested by the HUMAC NORM system (CSMi, Stoughton, MA) with the eccentric/concentric contraction mode at an angular velocity of 60 degrees/s.Isokinetic tests were performed five times for each participant, and each test was separated by a rest period of 3 min.The Muscle strength was present as a peak torque which was normalized to body weight (Unit:Nm/kg). The participants are assessed at Pre-intervention, 3-month, 6-month, 9-month-follow-up.	Pre-intervention, 3-month, 6-month, 9-month-follow-up
Secondary	Change from baseline hip muscle strength	Extension and flexion of hip were tested by the HUMAC NORM system (CSMi, Stoughton, MA) with the eccentric/concentric contraction mode at an angular velocity of 60 degrees/s.Isokinetic tests were performed five times for each participant, and each test was separated by a rest period of 3 min.The Muscle strength was present as a peak torque which was normalized to body weight (Unit:Nm/kg). The participants are assessed at Pre-intervention, 3-month, 6-month, 9-month-follow-up.	Pre-intervention, 3-month, 6-month, 9-month-follow-up
Secondary	Change from baseline knee muscle strength	Extension and flexion of knee were tested by the HUMAC NORM system (CSMi, Stoughton, MA) with the eccentric/concentric contraction mode at an angular velocity of 60 degrees/s.Isokinetic tests were performed five times for each participant, and each test was separated by a rest period of 3 min.The Muscle strength was present as a peak torque which was normalized to body weight (Unit:Nm/kg). The participants are assessed at Pre-intervention, 3-month, 6-month, 9-month-follow-up.	Pre-intervention, 3-month, 6-month, 9-month-follow-up
Secondary	Change from baseline SF-36 questionnaire assessment	SF-36 consists of eight scaled scores, which are the weighted sums of the questions in their section. Each scale is directly transformed into a 0-100 scale on the assumption that each question carries equal weight. The lower score the more disability. The higher the score the less disability. Eight sections including physical function, role limitation due to physical problems, bodily pain, general health, vitality, social functioning, role limitation due to emotional problems, and mental health. Additionally, the eight health domains can be used to provide a physical component summary and mental component summary score. The outcome measurement is assessed at Pre-intervention, 3-month, 6-month, 9-month-follow-up.	Pre-intervention, 3-month, 6-month, 9-month-follow-up
Secondary	High-density lipoprotein from blood sample	High-density lipoprotein are measured at Pre-intervention, 3-month, 6-month, 9-month-follow-up.	Pre-intervention, 3-month, 6-month, 9-month-follow-up
Secondary	Triglyceride from blood sample	Triglyceride are measured at Pre-intervention, 3-month, 6-month, 9-month-follow-up.	Pre-intervention, 3-month, 6-month, 9-month-follow-up
Secondary	Fasting blood glucose from blood sample	Fasting blood glucose are measured at Pre-intervention, 3-month, 6-month, 9-month-follow-up.	Pre-intervention, 3-month, 6-month, 9-month-follow-up
Secondary	Blood pressure	Diastolic and systolic blood pressure are measured at Pre-intervention, 3-month, 6-month, 9-month-follow-up.	Pre-intervention, 3-month, 6-month, 9-month-follow-up
Secondary	Weight parameters of the subjects	Weight (kg) are measured at Pre-intervention, 3-month, 6-month, 9-month-follow-up.	Pre-intervention, 3-month, 6-month, 9-month-follow-up
Secondary	Height parameters of the subjects	Height (cm) are measured at Pre-intervention, 3-month, 6-month, 9-month-follow-up.	Pre-intervention, 3-month, 6-month, 9-month-follow-up
Secondary	Waistline parameters of the subjects	Waistline (cm) are measured at Pre-intervention, 3-month, 6-month, 9-month-follow-up.	Pre-intervention, 3-month, 6-month, 9-month-follow-up