Treatment of Melasma With Jessner's Solution vs. Trichloroacetic Acid

Melasma Clinical Trial

Official title:

Treatment of Melasma With Jessner's Solution vs. Trichloroacetic Acid: A Comparison of Clinical Efficacy

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00166192
• Other study ID #: IRB00024850
• Status: Completed
• Phase: Phase 4
• First received: September 13, 2005
• Last updated: November 12, 2013
• Start date: January 2008
• Est. completion date: November 2013

Study information

• Verified date: November 2013
• Source: Emory University
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Food and Drug Administration
• Study type: Interventional

Clinical Trial Summary

Melasma is an acquired discoloration of the skin characterized by brown patches. Chemical peels using agents such as Jessner's solution and trichloroacetic acid (TCA) are commonly used to treat melasma. A chemical peel involves applying the peeling agent to the skin for a short period. The skin will peel similar to a sunburn, and moisturizers are applied to the skin. Although both agents are well-accepted, there have been no good comparisons of the two agents. The purpose of this study is determine if there is a difference in the effectiveness of these two agents.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 19
• Est. completion date: November 2013
• Est. primary completion date: January 2010
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Adults > 18 years old

• Clinical diagnosis of melasma

• Mental capacity to give informed consent

Exclusion Criteria:

• Pregnancy

• H/o allergy to Jessner's solution, tricholoracetetic acid, tretinoin, or hydroquinone

• Active dermatitis

• Presence of cutaneous infection

Study Design

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Melasma

Intervention

Procedure:
• Jessner's solution chemical peel

• Trichloroacetic acid chemical peel

Locations

Country	Name	City	State
United States	Emory University Dermatology Clinic	Atlanta	Georgia

Sponsors (1)

Lead Sponsor	Collaborator
Emory University

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Clinical efficacy by clinician's evaluation	Hyperpigmenation Global Score	3 months	No
Secondary	Efficacy by subject's evaluation	Hyperpigmentation Global Score	3 months	No