Melanoma Clinical Trial
Official title:
Study of Circulating Tumor Cells Before and After Treatment in Patients With Metastatic Melanoma.
Circulating tumor cells (CTC) are the subject of increasing interest in clinical oncology as
a prognostic factor and predictor of therapeutic response. The detection of CTC by
immunomagnetic method has proved its reliability and its usefulness for monitoring breast
cancer, colon and prostate in the metastatic and immunomagnetic detection system
(CellSearch, Veridex LLC) was approved by the FDA in these indications. However, to date
there is no reliable method to detect CTCs in melanoma (CMC). Studies based on PCR
amplification of mRNA by reverse specific melanoma is disappointing. Recently, a new
detection system of CMC immunomagnetic was presented (CellSearch, Veridex LLC, United
States). This system has the advantage of combining immunomagnetic selection step and a step
of identifying by immunofluorescence. A preclinical study on serial dilutions of melanoma
cells has shown encouraging results. The investigators propose a prospective study of the
CellSearch system in patients with melanoma.
Primary objective: To determine the effect of treatment on the number of circulating
melanoma cells in patients with metastatic melanoma.
Secondary objectives:
- determine the percentage of patients with metastatic melanoma with melanoma cells
circulating
- seek a relationship between the number of circulating melanoma cells and prognosis in
patients with metastatic melanoma
- seek a relationship between the change in the number of circulating melanoma cells
before / after treatment and tumor response in patients with metastatic melanoma
n/a
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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