Melanoma (Skin) Clinical Trial
Official title:
Integrated Molecular Signature for the Prediction of Response to Carboplatin/Paclitaxel-Based Chemotherapy in Metastatic Melanoma
RATIONALE: Studying samples of tissue in the laboratory from patients receiving carboplatin
and paclitaxel with or without sorafenib tosylate may help doctors learn more about the
effects of this treatment on cells. It may also help doctors understand how well patients
respond to treatment.
PURPOSE: This research study is studying biomarkers in predicting response to chemotherapy
in patients with advanced or metastatic melanoma previously treated with carboplatin and
paclitaxel with or without sorafenib tosylate.
OBJECTIVES:
- To independently correlate the gene expression and promoter methylation profiles to
chemotherapy response in patients with advanced or metastatic melanoma treated with
carboplatin and paclitaxel with versus without sorafenib on clinical trial ECOG-E2603.
- To develop a predictive model of chemotherapy response utilizing integrated analysis of
gene expression and promoter methylation data.
- To evaluate whether the NER pathway haplotypes are associated with platinum drug
resistance and survival.
OUTLINE: This is a multicenter study.
Archived paraffin-embedded tissue samples are analyzed for gene expression and promoter
methylation profiles, and genes involved in the NER pathway.
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