Malignant Melanoma Clinical Trial
Official title:
Long-term Outcome After Radical Lymph Node Dissection of Malignant Melanoma. Comparison Between Regional Versus General Anesthesia With Respect to Impact of Perioperative Immunoediting and Validation of New Potential Predictive Biomarkers
Studies in animals and retrospective studies in humans show that regional anesthesia reduces
metastatic cancer dissemination.
The investigators hypothesize that in patients suffering from malignant melanoma who have to
undergo radical inguinal lymph node dissection immune function will be less compromised and
long term survival will be superior when spinal anesthesia is compared to general
anesthesia.
Results of basic science indicate that regional anesthesia prevents perioperative immunosuppression and reduces postoperative metastatic cancer dissemination. If this would occur in humans, optimised anesthetic management might improve long-term outcome after cancer surgery. ;
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
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