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Safety and Immunogenicity of Pvs25-IMX313/Matrix-M1 Vaccine

Malaria, Vivax Clinical Trial

Official title:
A Phase Ia Study to Assess Safety and Immunogenicity of the Plasmodium Vivax Malaria Vaccine Candidate Pvs25-IMX313 in Matrix-M1 Adjuvant in Healthy Adults Living in the UK

Clinical Trial Summary

This is an open-label, single-centre, non-randomised, first-in-human Phase Ia study to assess the safety and immunogenicity of the Pvs25-IMX313 vaccine, administered in Matrix-M1 adjuvant.

Clinical Trial Description

Volunteers will be recruited into one of three groups (n=8-10 per group) at the Centre for Clinical Vaccinology and Tropical Medicine (CCVTM), Oxford over approximately 18 months. All volunteers will receive three doses of Pvs25-IMX313 in Matrix-M1, administered intramuscularly and given four weeks apart. Enrolment will be staggered with clinical and safety reviews, follow-up visits and monitoring via a diary card. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05270265
Study type Interventional
Source University of Oxford
Contact
Status Active, not recruiting
Phase Early Phase 1
Start date February 9, 2022
Completion date September 30, 2023
View Details
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